Table 4.

The cumulative excretion percentage (mole percent) of all metabolites in urine, bile and feces at different doses.

Biological sample	Dose (mg/kg)	M1 (%)	M2 (%)	M3 (%)	M4 (%)	Total (%)
Urine	12.5	2.81 ± 0.92	15.86 ± 3.66	9.57 ± 4.71	1.51 ± 0.36	29.75
0~48 h	25.0	2.82 ± 0.84	14.31 ± 4.08	8.04 ± 1.47	1.46 ± 0.40	26.63
	50.0	2.56 ± 0.55	11.99 ± 2.92	10.42 ± 3.44	1.55 ± 0.34	26.52
Bile	12.5	0.39 ± 0.01	4.80 ± 0.98	1.85 ± 0.95	1.20 ± 0.07	8.24
0~24 h	25.0	0.17 ± 0.05	4.61 ± 3.03	1.64 ± 0.84	1.22 ± 0.61	7.64
	50.0	0.11 ± 0.07	2.50 ± 1.56	0.77 ± 0.28	0.63 ± 0.21	1.76
Feces	12.5	0.03 ± 0.03	—	—	—	0.03
0~48 h	25.0	0.04 ± 0.02	—	—	—	0.04
	50.0	0.02 ± .0.01	—	—	—	0.02

“—” means undetected.

(Mean ± SD, n=6).