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. 2020 Feb 28;11:88. doi: 10.3389/fphar.2020.00088

Figure 1.

Figure 1

Compound C inhibited type I IFN production in dsDNA signaling. (A) L929 cells were treated with the different doses of Compound C for 24 h, and subjected to the CCK-8 assay. (B) Compound C inhibited the AMP-activated protein kinase (AMPK) activity as tested by Western blotting. (C) Enzyme-Linked Immunosorbent Assay (ELISA) analyses of IFNβ expression in L929 cells. The cells were transfected with HT-DNA after treated with the different doses of Compound C for 1 h. (D, E) ELISA analyses of IFNβ expression in L929 and BJ cells. The cells were transfected with HT-DNA and poly (I:C) after treated with indicate doses of Compound C. The experiments were performed at least three times. The statistical analyses were performed by Student’s-t test and the data are presented as mean ± SD (n = 3, * P < 0.05, **P < 0.01,***P < 0.001).