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. 2020 Feb 28;11:88. doi: 10.3389/fphar.2020.00088

Figure 2.

Figure 2

Compound C suppressed the expression of IFNβ by transfected dsDNA, but not cGAMP. (A, C, E) RT-qPCR analyses of IFNβ expression in L929 (A), BJ (C), THP1 (E) cells. The cells were transfected with HT-DNA after treated with indicated doses of Compound C. (B, D, F) RT-qPCR analyses of IFNβ expression in L929 (B), BJ (D), THP1 (F) cells. The cells were transfected with poly (I:C) after treated with indicated doses of Compound C for 1 h. (G) Western blot analyses of STING, P-STING, TBK1, P-TBK1, and GAPDH expression in BJ cells. The cell was transfected with HT-DNA, cGAMP and poly (I:C) after treated with indicate doses of Compound C. The experiments were performed at least three times. Data in bar graphs are presented as mean ± SD (n = 3−5) with asterisks indicating significant changes (NS Nonsignificance, *P < 0.05, **P < 0.01).