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. 2019 Oct 25;28(2):163–171. doi: 10.4062/biomolther.2019.071

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Copyright ©2020, The Korean Society of Applied Pharmacology

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 2. — Silibinin treatment up-regulates the expression of Nrf2 and HO-1 in pancreatic β-cells of diabetic rats. (A, B) Representative images of immunofluorescence labeling of insulin and 8-OHdG, and quantitative results of 8-OHdG-positive pancreatic β-cell percentage in islets. (C, D) Representative images of insulin/Nrf2 double immunofluorescence staining and quantitative analysis of Nrf2-positive pancreatic β-cell percentage in islets. (E, F) Representative images and the quantitative results of insulin/HO-1 double immunofluorescence staining. Magnification, ×200; scale bar, 50 μm. NG, normoglycemia; DB, diabetes; DS, diabetes+silibinin; DM, diabetes+metformin. Data are mean ± SEM (n=6 in each group). ^*p<0.05 vs. NG group; ^#p<0.05 vs. DB group.