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. 2019 Nov 18;28(2):172–183. doi: 10.4062/biomolther.2019.153

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Copyright ©2020, The Korean Society of Applied Pharmacology

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 7. — Effect of PBT-6 in mice with CIA. (A) Representative photographs of the hind paws on day 40 are shown (n=5). (B, C) The effect of PBT-6 on the clinical score and paw thickness of mice with CIA was evaluated. The values in B and C are the mean ± SD (^**p<0.01, ^***p<0.001 versus vehicle). (D) The effect of PBT-6 on the serum levels of TNF-α and IL-6 in mice with CIA was evaluated using ELISA. The values are the mean ± SD (^*p<0.05, ^***p<0.001 versus vehicle). (E) Specimens of the removed arthritic paws were stained with H&E and IHC (original magnification 100×). (F) Histopathological scores including inflammation, cartilage, and bone destruction were analyzed by two independent pathologists (^**p<0.01, ^***p<0.001 versus vehicle).