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. 2020 Feb 28;11:183. doi: 10.3389/fphar.2020.00183

Figure 8.

Figure 8

The effect of ligands of mGlu2/3 receptors on expression of polo-like kinase 2 (PLK2) and phosphorylated α-synuclein at Ser129 in substantia nigra (SN) of acute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinson’s Disease (PD) mice model. Immunoblots (A) and relevant histograms (C, D) represent expression of PLK2 and phosphorylated α-synuclein at Ser129 in SN of each group. Band intensity of particular target proteins were normalized to β-actin or glyceraldehyde 3-phosphate dehydrogenase (GAPDH) level. **p < 0.01. N = 6 in (C); N = 3 in (D). Data were expressed as % of the normal + saline group and shown as the mean ± SEM. (B, E) Western blots represent expression of PLK2 and pS129 α-synuclein in SN of acute MPTP-treated mice with different drug intervention. *p < 0.05 compared with the other two groups. N = 3. Data were expressed as % of the MPTP + saline group and shown as the mean ± SEM.