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. 2020 Feb 28;11:174. doi: 10.3389/fphar.2020.00174

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Copyright © 2020 Ibuki, Shoda, Miwa, Ishida, Tsubota and Kurihara

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Lactoferrin suppressed hypoxia-inducible factors (HIF) activation in a luciferase assay. (A) Administration of lactoferrin significantly suppressed CoCl₂-induced HIF activation in ARPE19 cells. (B) Administration of lactoferrin significantly suppressed CoCl₂-induced HIF activation in 661w cells. **p < 0.01, ***p < 0.001, compared with CoCl₂ without topotecan and lactoferrin, n = 3.