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. 2020 Feb 28;11:174. doi: 10.3389/fphar.2020.00174

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Copyright © 2020 Ibuki, Shoda, Miwa, Ishida, Tsubota and Kurihara

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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A significant reduction of the CNV volume in RPE specific Hif1a conditional knockout mice. (A) Representative three-dimensional images of the CNV stained by IB4. (B) Quantification of the CNV volume. Note that the CNV volume in Hif1a ^f/f; Best1-Cre^tg/- mice was significantly reduced compared with the control. Hif1a ^f/f; Best1-Cre^-/-: 256.14 ± 160.37 μm³, Hif1a ^f/f; Best1-Cre^tg/-: 183.89 ± 91.26 μm³. Six mice for Hif1a ^f/f; Best1-Cre^-/- and Hif1a ^f/f; Best1-Cre^tg/-, respectively. *p < 0.05. n = 6.