Agarwal 2004.

Methods	Trial design: parallel Single centre, India
Participants	Couples with unexplained subfertility N randomised: IUI + OH 70; TI + OH 70 Age: IUI + OH 29.52 years (± 3.65); TI + OH 28.83 years (± 4.76) Duration of subfertility: IUI + OH 4.91 years (± 2.72); TI + OH 4.93 years (± 3.27) Basic fertility work‐up normal, semen normal according to WHO 1987 Previous treatment: no
Interventions	Comparison: IUI + OH versus TI + OH Stimulation method: 50 mg to 150 mg CC/day, day 3 to day 7 Ovulation: 10,000 IU hCG when not more than 4 follicles of > 16 mm were present Timing of IUI and TI: 36 hr to 40 hr after hCG Duration of treatment: 6 cycles max
Outcomes	Live birth and PR per couple and per cycle Miscarriage rate Ectopic PR Multiple pregnancies Pregnancy confirmed by USS showing gestational sac
Notes	ITT analysis: possible Author provided additional information Unbalanced groups: dropouts 37% in IUI group, 1% in TI group
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Random‐number table
Allocation concealment (selection bias)	Low risk	Adequate; sealed opaque envelopes
Blinding of participants and personnel (performance bias) All outcomes	Unclear risk	Blinding was not possible because of the nature of the interventions
Blinding of outcome assessment (detection bias) All outcomes	Low risk	Blinding was not possible because of the nature of the interventions and non‐blinding was not likely to affect the outcomes of interest
Incomplete outcome data (attrition bias) All outcomes	High risk	There was an unequal dropout in the treatment group due to financial reasons; Nr of withdrawals: IUI + OH 26 (37%); TI + OH 1 (total 19%)
Selective reporting (reporting bias)	Unclear risk	Reported on live birth, but authors provided additional information on ongoing pregnancies and twin pregnancies resulting in different data used for meta‐analysis
Other bias	Low risk	Baseline demographic characteristics similar between the 2 groups