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. 2020 Mar 2;2020(3):CD005004. doi: 10.1002/14651858.CD005004.pub3

6. Detailed summary results of included nonexperimental case‐control studies.

References Detailed summary results The Newcastle‐Ottawa Scale (NOS)
Bandera 2010 Reference category: lowest exposure
Endometrial cancer
Intermediate exposure: OR 1.04 (95% CI 0.72‐1.50)
Highest exposure: OR 0.76 (95% CI 0.48‐1.21)
Low risk:
Selection: 4/4 stars, low risk
Comparability: 2/2 stars, low risk
Exposure: 2/3 stars, difference in response rate between cases and controls or no designation
Total score: 8/9 stars, moderate quality.
Berroukche 2012 Reference category: lowest exposure
Prostate cancer
Intermediate exposure 1: OR 1.4 (95% CI 0.8‐2.2)
Intermediate exposure 2: OR 0.9 (95% CI 0.5‐1.4)
Highest exposure: OR 0.6 (95% CI 0.3‐1.1)
Low risk:
Selection: 3/4 stars, hospital controls
Comparability: 2/2 stars, low risk
Exposure: 3/3 stars, low risk
Total score: 8/9 stars, moderate quality.
Bonner 2005 Reference category: lowest exposure
Lung cancer
Intermediate exposure: OR 0.84 (95% CI 0.38‐1.85)
Highest exposure: OR 0.59 (95% CI 0.26‐1.37)
Low risk:
Selection: 3/4 stars, no description of source of controls
Comparability: 2/2 stars, low risk
Exposure: 2/3 stars, low risk
Total score: 7/9 stars, moderate quality.
Chen 2011 Oesophageal cancer
Reference category: lowest exposure
Intermediate exposure 1: OR 1.27 (95% CI 0.72‐1.89)
Intermediate exposure 2: OR 0.97 (95% CI 0.59‐2.56)
Highest exposure: OR 0.92 (95% CI 0.49‐2.32)
Low risk:
Selection: 3/4 stars, hospital controls
Comparability: 2/2 stars, low risk
Exposure: 3/3 stars, low risk
Total score: 8/9 stars, moderate quality.
Chen 2017a Oral cancer
Reference category: lowest exposure
Chen 2015
Highest exposure: OR 0.48 (95% CI 0.28‐0.82)
Chen 2016
Highest exposure: OR 0.501 (95% CI 0.284‐0.883)
Chen 2017a
non‐smokers
Highest exposure: OR 0.515 (95% CI 0.323‐0.821)
Former/current smokers
Highest exposure: OR 0.849 (95% CI 0.556‐1.298)
Non‐alcohol drinkers
Highest exposure: OR 0.551 (95% CI 0.372‐0.817)
Former/current alcohol drinkers
Highest exposure: OR 0.934 (95% CI 0.934‐1.563)
Low risk:
Chen 2015
Selection: 4/4 stars, low risk
Comparability: 2/2 stars, low risk
Exposure: 3/3 stars, low risk
Total score: 9/9 stars, high quality.
Chen 2016
Selection: 3/4 stars, hospital controls
Comparability: 2/2 stars, low risk
Exposure: 3/3 stars, low risk
Total score: 8/9 stars, moderate quality.
Chen 2017a
Selection: 3/4 stars, hospital controls
Comparability: 2/2 stars, low risk
Exposure: 3/3 stars, low risk
Total score: 8/9 stars, moderate quality.
Fu 2013 Oral cancer
Reference category: lowest exposure
Men
Intermediate exposure: OR 0.82 (95% CI 0.69‐1.07)
Highest exposure: OR 0.72 (95% CI 0.54‐0.93)
Women
Intermediate exposure: OR 1.00 (95% CI 0.80‐1.25)
Highest exposure: OR 0.93 (95% CI 0.74‐1.26)
Low risk:
Selection: 3/4 stars, hospital controls
Comparability: 2/2 stars, low risk
Exposure: 3/3 stars, low risk
Total score: 8/9 stars, moderate quality.
Gao 1994 Oesophageal cancer
Reference category: lowest exposure
Exposure assessment A: intake of green tea
Men
Highest exposure: OR 0.80 (95% CI 0.58‐1.09)
Women
Highest exposure: OR 0.50 (95% CI 0.30‐0.83)
Exposure assessment B: green tea consumption
Men
Intermediate exposure: OR 0.79 (95% CI 0.53‐1.17)
Highest exposure: OR 0.79 (95% CI 0.56‐1.13)
Women
Intermediate exposure: OR 0.77 (95% CI 0.39‐1.53)
Highest exposure: OR 0.34 (95% CI 0.17‐0.69)
Low risk:
Selection: 3/4 stars, hospital controls
Comparability: 2/2 stars, low risk
Exposure: 2/3 stars, non‐response rate difference between cases and controls or NR
Total score: 7/9 stars, moderate quality.
Gao 2005 Reference category: lowest exposure
Endometrial cancer
Highest exposure: OR 0.81 (95% CI 0.65‐1.00)
Low risk:
Selection: 4/4 stars, low risk
Comparability: 1/2 stars, the study did not control for smoking.
Exposure: 2/3 stars, nonresponse rate different between cases and controls or NR
Total score: 7/9 stars, moderate quality.
Gavrilas 2018 Colorectal cancer
Reference category: lowest exposure
Intermedaite exposure 1: OR 0.34 (95% CI 0.15‐0.76)
Intermediate exposure 2: OR 0.03 (95% CI 0.01‐0.10)
Highest exposure: OR 0.14 (95% CI 0.05‐0.34)
Low risk:
Selection: 3/4 stars, no description of controls
Comparability: 2/2 stars, low risk
Exposure: 2/3 stars, non‐response rate NR
Total score: 7/9 stars, moderate quality.
Goodman 2003 Ovarian cancer
Reference category: lowest exposure
Highest exposure: OR 0.9 (95% CI 0.6‐1.5)
Highest exposure A: OR 1.0 (95% CI 0.6‐1.9)
Highest exposure B: OR 0.9 (95% CI 0.5‐1.6)
Low risk:
Selection: 4/4 stars, low risk
Comparability: 1/2 stars, the study did not control for smoking
Exposure: 3/3 stars, low risk
Total score: 8/9 stars, moderate quality.
Goto 1990 Pancreatic cancer
Reference category: lowest exposure
Highest exposure: OR 0.34 (95% CI 0.17‐0.67)
Low risk:
Selection: 3/4 stars, no description of source of controls
Comparability: 2/2 stars, low risk
Exposure: 2/3 stars, non‐response rate different between cases and controls or NR
Total score: 7/9 stars, moderate quality.
Green 2014 Reference category: lowest exposure
Colorectal cancer
Intermediate exposure 1: OR 0.99 (95% CI 0.64‐1.52)
Intermediate exposure 2: OR 1.15 (95% CI 0.62‐2.13)
Highest exposure: OR 0.99 (95% CI 0.62‐1.58)
Proximal colon cancer
Intermediate exposure 1: OR 1.36 (95% CI 0.76‐2.41)
Intermediate exposure 2: OR 0.61 (95% CI 0.20‐1.83)
Highest exposure: OR 0.95 (95% CI 0.50‐1.78)
Distal colon cancer
Intermediate exposure 1: OR 0.75 (95% CI 0.38‐1.46)
Intermediate exposure 2: OR 1.31 (95% CI 0.55‐3.10)
Highest exposure: OR 0.97 (95% CI 0.47‐2.03)
Rectal cancer
Intermediate exposure 1: OR 0.91 (95% CI 0.48‐1.71)
Intermediate exposure 2: OR 1.49 (95% CI 0.67‐3.32)
Highest exposure: OR 1.05 (95% CI 0.53‐2.10)
Low risk:
Selection: 4/4 stars, low risk
Comparability: 2/2 stars, low risk
Exposure: 2/3 stars, non‐response rate different between cases and controls or NR
Total score: 8/9 stars, moderate quality.
Hakim 2000 Skin cancer
Reference category: lowest exposure
Highest exposure: OR 0.82 (95% CI 0.35‐1.90)
Low risk:
Selection: 4/4 stars, low risk
Comparability: 1/2 stars, the study did not control for smoking.
Exposure: 3/3 stars, low risk
Total score: 8/9 stars, moderate quality.
Han 2008 Reference category: lowest exposure
Lung cancer
Exposure assessment 1:
Highest exposure: OR 0.520 (95% CI 0.392‐0.691)
Exposure assessment 2:
Intermediate exposure 1: OR 0.222 (95% CI 0.127‐0.390)
Intermediate exposure 2: OR 0.687 (95% CI 0.448‐1.052)
Highest exposure: OR 0.734 (95% CI 0.476‐1.132)
Low risk:
Selection: 4/4 stars, low risk
Comparability: 2/2 stars, low risk
Exposure: 2/3 stars, non‐response rate different between cases and controls or NR
Total score: 8/9 stars, moderate quality.
Hemelt 2010 Bladder cancer
Reference category: lowest exposure
Exposure assessment 1:
Highest exposure: OR 0.95 (95% CI 0.68‐1.32)
Exposure assessment 2:
Intermediate exposure: OR 0.83 (95% CI 0.54‐1.27)
Highest exposure: OR 1.02 (95% CI 0.71‐1.48)
further divided by cups/d: < 4 cups/d OR 1.23 (95% CI 0.76‐1.97);
> 4 cups/d OR 0.83 (95% CI 0.53‐1.28)
Low risk:
Selection: 3/4 stars, hospital controls
Comparability: 2/2 stars, low risk
Exposure: 2/3 stars, non‐response rate different between cases and controls or NR
Total score: 7/9 stars, moderate quality.
Hoshiyama 1992 Reference category: lowest exposure
Single stomach cancer
Intermediate exposure: OR 1.2 (95% CI 0.8‐1.7)
Highest exposure: OR 0.9 (95% CI 0.6‐1.3)
Multiple stomach cancer
Intermediate exposure: OR 1.5 (95% CI 0.6‐3.5)
Highest exposure: OR 1.6 (95% CI 0.7‐3.9)
Low risk:
Selection: 4/4 stars, low risk
Comparability: 2/2 stars, low risk
Exposure: 3/3 stars, non‐response rate different between cases and controls or NR
Total score: 8/9 stars, moderate quality.
Hsu 2012 Reference category: lowest exposure
Nasopharyngeal carcinoma
Intermediate exposure: OR 0.58 (95% CI 0.35‐0.98)
Highest exposure: OR 0.61 (95% CI 0.40‐0.91)
Low risk:
Selection: 4/4 stars, low risk
Comparability: 2/2 stars, low risk
Exposure: 2/3 stars, non‐response rate different between cases and controls or NR
Total score: 8/9 stars, moderate quality.
Huang 1999 Huang 1999
Reference category: lowest exposure
Stomach cancer
Intermediate exposure 1: OR 0.88 (95% CI 0.73‐1.05)
Intermediate exposure 2: OR 1.08 (95% CI 0.90‐1.24)
Highest exposure: OR 0.90 (95% CI 0.73‐1.11)
Inoue 1994
Reference category: lowest exposure
Stomach cancer (total)
Highest exposure: OR 1.09 (95% CI 0.83‐1.43)
Subsite
Cardia
Highest exposure: OR 1.12 (95% CI 0.70‐1.79)
Middle
Highest exposure: OR 1.06 (95% CI 0.73‐1.54)
Antrum
Highest exposure: OR 1.10 (95% CI 0.78‐1.57)
Kato 1990a
Reference category: lowest exposure
Stomach cancer
Men
Intermediate exposure: RR 1.14 (95% CI 0.82‐1.60)
Highest exposure: RR 1.01 (95% CI 0.70‐1.47)
Women
Intermediate exposure: RR 0.71 (95% CI 0.45‐1.14)
Highest exposure: RR 0.81 (95% CI 0.51‐1.27)
High risk:
Huang 1999
Selection: 3/4 stars, hospital controls
Comparability: 2/2 stars, low risk
Exposure: 2/3 stars, non‐respondent described
Total score: 7/9 stars, moderate quality.
Kato 1990a
Selection: 2/4 stars, potential bias in selection of cases and hospital controls
Comparability: 1/2 stars, the study did not control for smoking.
Exposure: 2/3 stars, self‐reported exposure not within a structured interview or questionnaire.
Total score: 5/9 stars, low quality.
Inoue 1994
Selection: 3/4 stars, hospital controls
Comparability: 1/2 stars, the study did not control for smoking.
Exposure: 2/3 stars, self‐reported exposure not within a structured interview or questionnaire.
Total score: 6/9 stars, low quality.
Inoue 1998 Reference category: lowest exposure
Oesophageal cancer
Intermediate exposure 1: OR 1.02 (95% CI 0.50‐2.10)
Intermediate exposure 2: OR 1.07 (95% CI 0.58‐2.00)
Intermediate exposure 3: OR 0.96 (95% CI 0.50‐1.83)
Highest exposure: OR 1.14 (95% CI 0.55‐2.34)
Stomach cancer (also reported in Inoue 1994 in: Huang 1999 and Inoue 2009a)
Intermediate exposure 1: OR 1.00 (95% CI 0.77‐1.44)
Intermediate exposure 2: OR 0.96 (95% CI 0.70‐1.32)
Intermediate exposure 3: OR 1.01 (95% CI 0.74‐1.39)
Highest exposure: OR 0.69 (95% CI 0.48‐1.00)
Colon cancer
Intermediate exposure 1: OR 0.62 (95% CI 0.36‐1.05)
Intermediate exposure 2: OR 0.64 (95% CI 0.42‐1.00)
Intermediate exposure 3: OR 0.76 (95% CI 0.49‐1.17)
Highest exposure: OR 0.77 (95% CI 0.47‐1.26)
Rectal cancer
Intermediate exposure 1: OR 1.41 (95% CI 0.70‐2.83)
Intermediate exposure 2: OR 1.04 (95% CI 0.55‐1.98)
Intermediate exposure 3: OR 1.42 (95% CI 0.75‐2.69)
Highest exposure: OR 1.25 (95% CI 0.62‐2.51)
Low risk:
Selection: 3/4 stars, hospital controls
Comparability: 2/2 stars, low risk
Exposure: 2/3 stars, self‐reported exposure not within a structured interview or questionnaire.
Total score: 7/9 stars, moderate quality.
Inoue 2008 Reference category: lowest exposure
Breast cancer
Intermediate exposure: OR 0.65 (95% CI 0.45‐0.94)
Highest exposure: OR 1.00 (95% CI 0.82‐1.22)
Low risk:
Selection: 4/4 stars, low risk
Comparability: 1/2 stars, the study did not control for smoking
Exposure: 2/3 stars, non‐response rate different between cases and controls
Total score: 7/9 stars, moderate quality.
Islami 2009 Reference category: lowest exposure
Oesophageal cancer
Highest exposure: OR 0.89 (95% CI 0.38‐2.09)
Low risk:
Selection: 4/4 stars, low risk
Comparability: 2/2 stars, low risk
Exposure: 2/3 stars, non‐respondents described
Total score: 8/9 stars, moderate quality.
Iwasaki 2014 Reference category: lowest exposure
Breast cancer
Intermediate exposure: OR 0.86 (95% CI 0.53‐1.41)
Highest exposure: OR 1.27 (95% CI 0.75‐2.14)
Low risk:
Selection: 3/4 stars, hospital controls
Comparability: 2/2 stars, low risk
Exposure: 2/3 stars, non‐respondents described
Total score: 7/9 stars, moderate quality.
Ji 1996 Reference category: lowest exposure
Stomach cancer
Men
Exposure assessment A: green tea drinking status
Highest exposure: OR 0.96 (95% CI 0.77‐1.21)
Exposure assessment B: consumption of green tea leaves
Intermediate exposure 1: OR 1.06 (95% CI 0.76‐1.49)
Intermediate exposure 2: OR 1.15 (95% CI 0.82‐1.61)
Intermediate exposure 3: OR 0.88 (95% CI 0.55‐1.24)
Highest exposure: OR 0.76 (95% CI 0.55‐1.27)
Women
Exposure assessment A: green tea drinking status
Highest exposure: OR 0.77 (95% CI 0.52‐1.13)
Exposure assessment B: consumption of green tea leaves
Intermediate exposure: OR 0.74 (95% CI 0.45‐1.21)
Highest exposure: OR 0.81 (95% CI 0.46‐1.43)
Low risk:
Selection: 4/4 stars, low risk
Comparability: 2/2 stars, low risk
Exposure: 2/3 stars, non‐response rate different between cases and controls or NR
Total score: 8/9 stars, moderate quality.
Ji 1997 Reference category: lowest exposure
Men
Colon cancer
Exposure assessment A: green tea drinking habit
Highest exposure: OR 0.99 (95% CI 0.74‐1.33)
Exposure assessment B: green tea consumption
Intermediate exposure 1: OR 1.13 (95% CI 0.80‐1.61)
Intermediate exposure 2: OR 0.92 (95% CI 0.62‐1.37)
Highest exposure: OR 0.82 (95% CI 0.52‐1.28)
Exposure assessment C: lifetime green tea consumption
Intermediate exposure 1: OR 0.93 (95% CI 0.63‐1.35)
Intermediate exposure 2: OR 1.06 (95% CI 0.72‐1.56)
Highest exposure: OR 1.01 (95% CI 0.67‐1.51)
Rectal cancer
Exposure assessment A: green tea drinking habit
Highest exposure: OR 0.82 (95% CI 0.61‐1.10)
Exposure assessment B: green tea consumption
Intermediate exposure 1: OR 0.99 (95% CI 0.69‐1.41)
Intermediate exposure 2: OR 0.66 (95% CI 0.43‐0.99)
Highest exposure: OR 0.72 (95% CI 0.46‐1.13)
Exposure assessment C: lifetime green tea consumption
Intermediate exposure 1: OR 0.88 (95% CI 0.60‐1.27)
Intermediate exposure 2: OR 0.75 (95% CI 0.50‐1.13)
Highest exposure: OR 0.80 (95% CI 0.53‐1.23)
Pancreatic cancer
Exposure assessment A: green tea drinking habit
Highest exposure: OR 0.88 (95% CI 0.60‐1.31)
Exposure assessment B: green tea consumption
Intermediate exposure 1: OR 1.23 (95% CI 0.79‐1.92)
Intermediate exposure 2: OR 0.57 (95% CI 0.32‐1.03)
Highest exposure: OR 0.63 (95% CI 0.34‐1.17)
Exposure assessment C: lifetime green tea consumption
Intermediate exposure 1: OR 1.11 (95% CI 0.69‐1.79)
Intermediate exposure 2: OR 0.86 (95% CI 0.51‐1.45)
Highest exposure: OR 0.59 (95% CI 0.32‐1.07)
Women
Colon cancer
Exposure assessment A: green tea drinking habit
Highest exposure: OR 0.77 (95% CI 0.56‐1.06)
Exposure assessment B: green tea consumption
Intermediate exposure: OR 0.83 (95% CI 0.57‐1.21)
Highest exposure: OR 0.67 (95% CI 0.41‐1.10)
Exposure assessment C: lifetime green tea consumption
Intermediate exposure: OR 0.87 (95% CI 0.60‐1.27)
Highest exposure: OR 0.62 (95% CI 0.38‐1.02)
Rectal cancer
Exposure assessment A: green tea drinking habit
Highest exposure: OR 0.51 (95% CI 0.36‐0.73)
Exposure assessment B: green tea consumption
Intermediate exposure: OR 0.51 (95% CI 0.33‐0.79)
Highest exposure: OR 0.57 (95% CI 0.34‐0.97)
Exposure assessment C: lifetime green tea consumption
Intermediate exposure: OR 0.54 (95% CI 0.35‐0.84)
Highest exposure: OR 0.52 (95% CI 0.30‐0.89)
Pancreatic cancer:
Exposure assessment A: green tea drinking habit
Highest exposure: OR 0.47 (95% CI 0.29‐0.77)
Exposure assessment B: green tea consumption
Intermediate exposure: OR 0.47 (95% CI 0.25‐0.89)
Highest exposure: OR 0.53 (95% CI 0.25‐1.09)
Exposure assessment C: lifetime green tea consumption
Intermediate exposure: OR 0.59 (95% CI 0.32‐1.10)
Highest exposure: OR 0.38 (95% CI 0.18‐0.82)
Low risk:
Selection: 4/4 stars, low risk
Comparability: 2/2 stars, low risk
Exposure: 2/3 stars, non‐respondents described
Total score: 8/9 stars, moderate quality.
Jia 2016 Reference category: lowest exposure
Lung cancer + mesothelioma mortality
Intermediate exposure 1: OR 0.88 (95% CI 0.66‐0.87)
Intermediate exposure 2: OR 2.18 (95% CI 0.96‐3.50)
Highest exposure: OR 0.70 (95% CI 0.57‐0.86)
Low risk:
Selection: 4/4 stars, low risk
Comparability: 1/2 stars, the study did not control for smoking
Exposure: 2/3 stars, interview not blinded to case/control status
Total score: 7/9 stars, moderate quality.
Jian 2004 Prostate cancer
Reference category: lowest exposure
Exposure assessment A: green tea drinking habits
Highest exposure: OR 0.28 (95% CI 0.17‐0.47)
Exposure assessment B: intake of green tea
Intermediate exposure: OR 0.53 (95% CI 0.30‐0.94)
Highest exposure: OR 0.27 (95% CI 0.15‐0.48)
Low risk:
Selection: 3/4 stars, hospital controls
Comparability: 2/2 stars, low risk
Exposure: 3/3 stars, low risk
Total score: 8/9 stars, moderate quality.
Jin 2013 Reference category: lowest exposure
Lung cancer
Exposure assessment A: green tea drinking habits
Highest exposure: OR 0.78 (95% CI 0.65‐0.95)
Exposure assessment B: consumption of green tea
Intermediate exposure 1: OR 0.76 (95% CI 0.54‐1.07)
Intermediate exposure 2: OR 0.84 (95% CI 0.66‐1.08)
Highest exposure: OR 0.74 (95% CI 0.56‐0.99)
Low risk:
Selection: 4/4 stars, low risk
Comparability: 2/2 stars, low risk
Exposure: 3/3 stars, low risk
Total score: 9/9 stars, high quality.
Kakuta 2009 Reference category: lowest exposure
Endometrial cancer
Intermediate exposure 1: OR 0.77 (95% CI 0.37‐1.58)
Intermediate exposure 2: OR 0.61 (95% CI 0.30‐1.23)
Highest exposure: OR 0.33 (95% CI 0.15‐0.75)
Low risk:
Selection: 3/4 stars, hospital controls
Comparability: 2/2 stars, low risk
Exposure: 3/3 stars, low risk
Total score: 8/9 stars, moderate quality.
Kato 1990 Reference category: lowest exposure
Colon cancer
Highest exposure: RR 0.61 (95% CI 0.41‐0.91)
Rectal cancer
Highest exposure: RR 1.32 (95% CI 0.78‐2.23)
High risk:
Selection: 3/4 stars, potential for selection bias in cases
Comparability: 1/2 stars, the study did not control for smoking
Exposure: 2/3 stars, self‐reported exposure not within a structured interview or questionnaire.
Total score: 6/9 stars, low quality.
Kono 1988 Stomach cancer
Reference category: lowest exposure
Population controls
Highest exposure: OR 0.3 (95% CI 0.1‐0.7)
Hospital controls
Highest exposure: OR 0.5 (95% CI 0.3‐1.1)
High risk:
Selection: 4/4 stars when using population controls and 3/4 when using hospital controls
Comparability: 2/2 stars, low risk
Exposure: 1/3 stars, different methods of exposure ascertainment in cases and controls and self‐reported exposure not within a structured interview or questionnaire.
Total score: 7/9 stars, moderate quality and 6/9 stars low quality.
Kubik 2008 Kubik 2008
Reference category: lowest exposure (OR for trend only reported)
Lung cancer
Men nonsmokers
Highest exposure: OR 1.08 (95% CI 0.56‐2.08)
Men smokers
Highest exposure: OR 0.93 (95% CI 0.63‐1.38)
Women nonsmokers
Highest exposure: OR 0.88 (95% CI 0.61‐1.27)
Women smokers
Highest exposure: OR 1.09 (95% CI 0.80‐1.49)
Data on former smokers who quit from 10 to < 20 years were excluded from the reported analysis. Previous report on fewer female cases reported in Kubik 2004.
Kubik 2004
Reference category: lowest exposure
Lung cancer
Intermediate exposure: OR 0.97 (95% CI 0.69‐1.38)
Highest exposure: OR 1.02 (95% CI 0.74‐1.40)
Also analysis available stratified by smoking habits
Subsequent report in Kubik 2008 with longer recruitment of women from the same area
Low risk:
Kubik 2004
Selection: 3/4 stars, hospital controls
Comparability: 2/2 stars, low risk
Exposure: 2/3 stars, non‐response rate different between cases and controls or NR
Total score: 7/9 stars, moderate quality.
Kubik 2008
Selection: 3/4 stars, hospital controls
Comparability: 2/2 stars, low risk
Exposure: 2/3 stars, non‐response rate different between cases and controls or NR
Total score: 7/9 stars, moderate quality.
Kuo 2009 Leukaemia
Green‐tea‐only consumption compared to no‐tea consumption
Cases exposed = 9, controls exposed = 24, cases not exposed = 63, controls not exposed = 123
OR 0.73 (95% CI 0.32‐1.67)
Consumption of green tea with other types of tea compared to no‐tea consumption
Cases exposed = 17, controls exposed = 61, cases not exposued = 63, controls not exposed = 123
OR 0.54 (95% CI 0.29‐1.01)
High risk:
Selection: 4/4 stars, low risk
Comparability: 0/2 stars, only crude analysis without adjustment for confounding factors
Exposure: 2/3 stars, non‐response rate different between cases and controls or NR
Total score: 6/9 stars, low quality.
Lassed 2016 Reference category: lowest exposure
Postate cancer
Intermediate exposure: OR 0.64 (95% CI 0.36‐1.15)
Highest exposure: OR 0.40 (95% CI 0.08‐1.92)
High risk:
Selection: 3/4 stars, hospital controls
Comparability: 0/2 stars, crude analysis with no adjustment for confounding factors
Exposure: 3/3 stars, low risk
Total score: 6/9 stars, low quality.
Le Marchand 2000 Reference category: lowest exposure
Lung cancer
Intermediate exposure 1: OR 1.0 (95% CI 0.6‐1.7)
Intermediate exposure 2: OR 0.7 (95% CI 0.4‐1.3)
Highest exposure: OR 0.9 (95% CI 0.5‐1.6)
Low risk:
Selection: 4/4 stars, low risk
Comparability: 2/2 stars, low risk
Exposure: 3/3 stars, low risk
Total score: 9/9 stars, high quality.
Lee 2017 Reference category: lowest exposure
Prostate cancer
Exposure assessment A
Highest exposure: OR 0.60 (95% CI 0.37‐0.98)
Exposure assessment B
Intermediate exposure 1: OR 1.53 (95% CI 0.39‐5.93)
Intermediate exposure 2: OR 0.16 (95% CI 0.01‐2.22)
Highest exposure: OR 0.34 (95% CI 0.02‐6.05)
Low risk:
Selection: 3/4 stars, hospital controls
Comparability: 2/2 stars, low risk
Exposure: 2/3 stars, non‐response rate different between cases and controls or NR
Total score: 7/9 stars, moderate quality.
Lei 1994 Reference category: lowest exposure
Lung cancer
Highest exposure: OR 0.71 (95% CI 0.43‐1.18)
High risk:
Selection: 1/4 stars, no description of identification of cases with potential selection bias and hospital controls
Comparability: 1/2 stars, the study did not control for smoking.
Exposure: 1/3 star, no description of exposure ascertainment and non‐response rate between cases and controls NR
Total score: 3/9 stars, low quality.
Leung 2016 Reference category: lowest exposure
Ovarian cancer
Exposure assessment A
Highest exposure: OR 0.84 (95% CI 0.54‐1.30)
Exposure assessment B
Intermediate exposure 1: OR 1.03 (95% CI 0.50‐2.00)
Intermediate exposure 2: OR 0.78 (95% CI 0.37‐1.55)
Highest exposure: OR 0.77 (95% CI 0.39‐1.46)
Low risk:
Selection: 4/4 stars, low risk
Comparability: 2/2 stars, low risk
Exposure: 3/3 stars, low risk
Total score: 9/9 stars, high quality
Li 2011a Reference category: lowest exposure
Results using population controls
All cancer
Exposure assessment A
Highest exposure: OR 0.78 (95% CI 0.60‐1.01)
Exposure assessment B
Intermediate exposure: OR 0.71 (95% CI 0.47‐1.08)
Highest exposure: OR 0.51 (95% CI 0.27‐0.74)
Breast cancer
Exposure assessment A
Highest exposure: OR 0.61 (95% CI 0.32‐1.18)
Exposure assessment B
Intermediate exposure: OR 0.60 (95% CI 0.24‐1.50)
Highest exposure: OR 0.07 (95% CI 0.01‐0.47)
Colorectal cancer
Exposure assessment A
Highest exposure: OR 0.62 (95% CI 0.42‐0.92)
Exposure assessment B
Intermediate exposure: OR 0.55 (95% CI 0.28‐1.06)
Highest exposure: OR 0.45 (95% CI 0.25‐0.82)
Leukaemia
Exposure assessment A
Highest exposure: OR 1.55 (95% CI 0.61‐3.96)
Exposure assessment B
Intermediate exposure: OR not estimable
Highest exposure: OR 0.57 (95% CI 0.07‐4.79)
Results using hospital controls
All cancer
Exposure assessment A
Highest exposure: OR 0.77 (95% CI 0.59‐1.00)
Exposure assessment B:
Intermediate exposure: OR 0.60 (95% CI 0.40‐0.92)
Highest exposure: OR 0.51 (95% CI 0.31‐0.83)
Breast cancer
Exposure assessment A
Highest exposure: OR 0.55 (95% CI 0.28‐1.06)
Exposure assessment B
Intermediate exposure: OR 0.54 (95% CI 0.22‐1.33)
Highest exposure: OR 0.06 (95% CI 0.01‐0.61)
Colorectal cancer
Exposure assessment A
Highest exposure: OR 0.67 (95% CI 0.45‐0.99)
Exposure assessment B
Intermediate exposure: OR 0.51 (95% CI 0.26‐0.99)
Highest exposure: OR 0.52 (95% CI 0.29‐0.94)
Leukaemia
Exposure assessment A
Highest exposure: OR 1.46 (95% CI 0.55‐3.84)
Exposure assessment B
Intermediate exposure: OR not estimable
Highest exposure: OR 0.65 (95% CI 0.08‐5.63)
Low risk:
Selection: 4/4 stars when using population controls and 3/4 when using hospital controls, low risk
Comparability: 2/2 stars, low risk
Exposure: 2/3 stars, non‐response rate different between cases and controls or NR
Total score: 8/9 stars and 7/9 stars, moderate quality.
Li 2014 Reference category: lowest exposure
Prostate cancer
Highest exposure: OR 0.59 (95% CI 0.40‐0.87)
Low risk:
Selection: 4/4 stars, low risk
Comparability: 1/2 stars, the study did not control for smoking
Exposure: 2/3 stars, self‐reported exposure not within a structured interview or questionnaire.
Total score: 7/9 stars, moderate quality.
Li 2016 Reference category: lowest exposure
Breast cancer
Highest exposure: OR 1.20 (95% CI 0.80‐1.78)
Low risk:
Selection: 3/4 stars, hospital controls
Comparability: 1/2 stars, the study did not control for smoking
Exposure: 3/3 stars, low risk
Total score: 7/9 stars, moderate quality.
Lin 2012 Reference category: highest exposure
Lung cancer
Intermediate exposure: RR 3.01 (95% CI 1.13‐8.05)
Lowest exposure: RR 6.34 (95% CI 2.69‐14.91)
High risk:
Selection: 3/4 stars, hospital controls
Comparability: 1/2 stars, the study did not control for smoking.
Exposure: 2/3 stars, self‐reported exposure not within a structured interview or questionnaire.
Total score: 6/9 stars, low quality.
Liu 2010 Reference category: lowest exposure
Stomach cancer:
Highest exposure: OR 0.42 (95%CI 0.32‐0.55)
Low risk:
Selection: 4/4 stars, low risk
Comparability: 2/2 stars, low risk
Exposure: 3/3 stars, low risk
Total score: 9/9 stars, high quality.
Liu 2017 Reference category: highest exposure
Leukaemia
Lowest exposure: OR 0.71 (95% CI 0.46‐1.07)
Low risk:
Selection: 3/4 stars, hospital controls
Comparability: 2/2 stars, low risk
Exposure: 3/3 stars, low risk
Total score: 8/9 stars, moderate quality.
Mao 2011 Reference category: lowest exposure
Stomach cancer
Exposure assessment A: green‐tea drinking status
Intermediate exposure: OR 0.58 (95% CI 0.46‐5.03)
Highest exposure: OR 1.02 (95% CI 0.70‐1.64)
Exposure assessment B: green tea consumption
Intermediate exposure 1: OR 0.88 (95% CI 0.57‐1.36)
Intermediate exposure 2: OR 1.15 (95% CI 0.76‐2.35)
Highest exposure: OR 1.13 (95% CI 0.52‐2.67)
High risk:
Selection: 2/4 stars, hospital controls with no description
Comparability: 2/2 stars, low risk
Exposure: 2/3 stars, self‐reported exposure not within a structured interview or questionnaire.
Total score: 6/9 stars, low quality.
Mizoo 2013 Reference category: lowest exposure
Breast cancer
Intermediate exposure 1: OR 0.97 (95% CI 0.71‐1.33)
Intermediate exposure 2: OR 0.63 (95% CI 0.43‐0.93)
Highest exposure: OR 0.72 (95% CI 0.46‐1.12)
Low risk:
Selection: 3/4 stars, hospital controls
Comparability: 1/2 stars, the study did not control for smoking
Exposure: 3/3 stars, low risk
Total score: 7/9 stars, moderate quality.
Mizuno 1992 Reference category: lowest exposure
Pancreatic cancer
Highest exposure: OR 1.94 (95% CI 1.06‐3.55)
High risk:
Selection: 3/4 stars, hospital controls
Comparability: 1/2 stars, the study did not control for smoking
Exposure: 2/3 stars, self‐reported exposure not within a structured interview or questionnaire.
Total score: 6/9 stars, low quality.
Mu 2003 Reference category: lowest exposure
Stomach cancer (Mu 2005)
Intermediate exposure 1: OR 1.09 (95% CI 0.53‐2.23)
Intermediate exposure 2: OR 0.44 (95% CI 0.19‐1.01)
Highest exposure: OR 0.40 (95% CI 0.14‐1.09)
Exposure assessment B: green tea intake
Highest exposure: OR 0.59 (95% CI 0.34‐1.01)
Liver cancer (Li 2011b)
Intermediate exposure 1: OR 1.21 (95% CI 0.62‐2.36)
Intermediate exposure 2: OR 0.76 (95% CI 0.38‐1.51)
Highest exposure: OR 0.55 (95% CI 0.28‐1.09)
Oesophageal cancer
Intermediate exposure 1: OR 1.13 (95% CI 0.67‐1.92)
Intermediate exposure 2: OR 0.78 (95% CI 0.46‐1.34)
Highest exposure: OR 0.58 (95% CI 0.35‐0.97)
Low risk:
Li 2011b
Selection: 4/4 stars, low risk
Comparability: 2/2 stars, low risk
Exposure: 2/3 stars, non‐response rate different between cases and controls or NR
Total score: 8/9 stars, moderate quality.
Mu 2003
Selection: 3/4 stars, potential selection bias for cases
Comparability: 2/2 stars, low risk
Exposure: 2/3 stars, non‐response rate different between cases and controls or NR
Total score: 7/9 stars, moderate quality.
Mu 2005
Selection: 4/4 stars, low risk
Comparability: 2/2 stars, low risk
Exposure: 2/3 stars, non‐response rate different between cases and controls or NR
Total score: 8/9 stars, moderate quality.
Nagle 2010 Reference category: lowest exposure
Ovarian cancer
Intermediate exposure 1: OR 0.77 (95% CI 0.61‐0.98)
Intermediate exposure 2: OR 0.85 (95% CI 0.63‐1.15)
Intermediate exposure 3: OR 0.80 (95% CI 0.54‐1.19)
Intermediate exposure 4: OR 0.92 (95% CI 0.57‐1.49)
Highest exposure: OR 0.82 (95% CI 0.38‐1.79)
Low risk:
Selection: 4/4 stars, low risk
Comparability: 2/2 stars, low risk
Exposure: 2/3 stars, non‐response rate different between cases and controls or NR
Total score: 8/9 stars, moderate quality
Oze 2014 Reference category: lowest exposure
Upper aerodigestive tract cancer
Intermediate exposure 1: OR 1.25 (95% CI 0.98–1.60)
Intermediate exposure 2: OR 1.02 (95% CI 0.77–1.34)
Highest exposure: OR 1.39 (95% CI 1.13–1.70)
Subsite
Oesophageal cancer
Intermediate exposure 1: OR 1.20 (95% CI 0.82–1.77)
Intermediate exposure 2: OR 1.00 (95% CI 0.65–1.55)
Highest exposure: OR 1.31 (95% CI 0.95–1.81)
Oral, pharyngeal and laryngeal cancer
Intermediate exposure 1: OR 1.34 (95% CI 0.97–1.86)
Intermediate exposure 2: OR 1.03 (95% CI 0.71–1.50)
Highest exposure: OR 1.47 (95% CI 1.12–1.93)
Available also stratified analysis by smoking status (never, ever) and alcoholic drinker
Low risk:
Selection: 4/4 stars, low risk
Comparability: 2/2 stars, low risk
Exposure: 2/3 stars, self‐reported exposure not within a structured interview or questionnaire.
Total score: 8/9 stars, moderate quality.
Peng 2013 Reference category: lowest exposure
Colorectal cancer
Highest exposure: OR 0.54 (95% CI 0.41‐0.72)
Low risk:
Selection: 4/4 stars, low risk
Comparability: 1/2 stars, the study did not control for smoking.
Exposure: 2/3 stars, self‐reported exposure not within a structured interview or questionnaire.
Total score: 7/9 stars, moderate quality
Peng 2015 Reference category: lowest exposure
Oesophageal cancer
Highest exposure: OR 0.63 (95% CI 0.45‐0.91)
Low risk:
Selection: 4/4 stars, low risk
Comparability: 2/2 stars, low risk
Exposure: 2/3 stars, self‐reported exposure not within a structured interview or questionnaire.
Total score: 8/9 stars, moderate quality.
Ruan 2010 Reference category: lowest exposure
Nasopharyngeal cancer
Highest exposure: OR 0.44 (95% CI 0.36–0.54)
Low risk:
Selection: 3/4 stars, hospital controls
Comparability: 1/2 stars, the study did not control for smoking
Exposure: 3/3 stars, low risk
Total score: 7/9 stars, moderate quality.
Setiawan 2001 Reference category: lowest exposure
Stomach cancer
Exposure assessment A
Highest exposure: OR 0.52 (95% CI 0.29–0.94)
Exposure assessment B
Intermediate exposure: OR 0.70 (95% CI 0.36–1.36)
Highest exposure: OR 0.39 (95% CI 0.15–1.01)
Low risk:
Selection: 4/4 stars, low risk
Comparability: 2/2 stars, low risk
Exposure: 2/3 stars, non‐response rate different between cases and controls or NR
Total score: 8/9 stars, moderate quality.
Shrubsole 2009 Reference category: lowest exposure
Breast cancer
Exposure assessment A
Highest exposure: OR 0.88 (95% CI 0.79–0.98)
Exposure assessment B
Intermediate exposure 1: OR 0.89 (95% CI 0.73–1.08)
Intermediate exposure 2: OR 0.93 (95% CI 0.77–1.12)
Intermediate exposure 3: OR 0.72 (95% CI 0.59–0.88)
Highest exposure: OR 0.97 (95% CI 0.80–1.16)
Stratified analysis also available in pre‐ and post‐menopausal women
Low risk:
Selection: 4/4 stars, low risk
Comparability: 1/2 stars, the study did not control for smoking.
Exposure: 2/3 stars, self‐reported exposure not within a structured interview or questionnaire.
Total score: 7/9 stars, moderate quality.
Song 2008 Reference category: lowest exposure
Ovarian cancer
Intermediate category: OR 0.82 (95% CI 0.66‐1.04)
Highest exposure: OR 0.46 (95% CI 0.26‐0.84)
Low risk:
Selection: 4/4 stars, low risk
Comparability: 2/2 stars, low risk
Exposure: 2/3 stars, self‐reported exposure not within a structured interview or questionnaire.
Total score: 8/9 stars, moderate quality
Sonoda 2004 Reference category: lowest exposure
Prostate cancer
Intermediate exposure 1: OR 0.99 (95% CI 0.48‐2.03)
Intermediate exposure 2: OR 0.79 (95% CI 0.38‐1.63)
Highest exposure: OR 0.67 (95% CI 0.27‐1.64)
Low risk:
Selection: 3/4 stars, hospital controls
Comparability: 2/2 stars, low risk
Exposure: 2/3 stars, self‐reported exposure not within a structured interview or questionnaire.
Total score: 7/9 stars, moderate quality.
Tajima 1985 Reference category: lowest exposure
Stomach cancer
Highest exposure: OR 0.64, CIs NR
Colon cancer
Highest exposure: OR 0.97, CIs NR
Rectal cancer
Highest exposure: OR 0.91, CIs NR
High risk:
Selection: 3/4 stars, hospital controls
Comparability: 1/2 stars, the study did not control for smoking
Exposure: 2/3 stars, self‐reported exposure not within a structured interview or questionnaire.
Total score: 6/9 stars, low quality.
Takezaki 2000 Reference category: lowest exposure
Pharynx (hypopharynx) cancer
Intermediate exposure: OR 0.8 (95% CI 0.4‐1.5)
Highest exposure: OR 0.8 (95% CI 0.3‐2.3)
Oesophageal cancer
Intermediate exposure: OR 0.8 (95% CI 0.6‐1.1)
Highest exposure: OR 0.7 (95% CI 0.4‐1.2)
Analysis also reported for upper, middle and lower third of the oesophagus
Low risk:
Selection: 3/4 stars, hospital controls
Comparability: 2/2 stars, low risk
Exposure: 3/3 stars, low risk
Total score: 8/9 stars, moderate quality.
Takezaki 2001 Reference category: lowest quartile
Adenocarcinoma
Men
Intermediate exposure 1: OR 1.06 (95% CI 0.72‐1.57)
Intermediate exposure 2: OR 1.11 (95% CI 0.74‐1.66)
Highest exposure: OR 1.33 (95% CI 0.83‐2.15)
Women
Intermediate exposure 1: OR 0.98 (95% CI 0.58‐1.66)
Intermediate exposure 2: OR 1.14 (95% CI 0.68‐1.93)
Highest exposure: OR 1.14 (95% CI 0.61‐2.12)
Squamous cell and small‐cell carcinoma
Men
Intermediate exposure 1: OR 0.99 (95% CI 0.67‐1.47)
Intermediate exposure 2: OR 1.17 (95% CI 0.78‐1.73)
Highest exposure: OR 1.08 (95% CI 0.66‐1.75)
Women
Intermediate exposure 1: OR 0.36 (95% CI 0.14‐0.93)
Intermediate exposure 2: OR 0.41 (95% CI 0.16‐1.04)
Highest exposure: OR 0.49 (95% CI 0.17‐1.46)
Low risk:
Selection: 3/4 stars, hospital controls
Comparability: 2/2 stars, low risk
Exposure: 3/3 stars, low risk
Total score: 8/9 stars, moderate quality.
Tewes 1990 Reference category: lowest exposure
Lung cancer
Highest exposure: OR 2.74 (95% CI 1.10‐6.80)
Low risk:
Selection: 3/4 stars, case identification with no independent validation
Comparability: 2/2 stars, low risk
Exposure: 2/3 stars, self‐reported exposure not within a structured interview or questionnaire.
Total score: 7/9 stars, moderate quality.
Tse 2017 Reference category: lowest exposure
Prostate cancer
Highest exposure: OR 0.56 (95% CI 0.34‐0.91)
High risk:
Selection: 3/4 stars, hospital controls
Comparability: 1/2 stars, the study did not control for smoking.
Exposure: 2/3 stars, self‐reported exposure not within a structured interview or questionnaire.
Total score: 6/9 stars, low quality.
Wakai 2004 Reference category: lowest exposure
Bladder cancer
Intermediate exposure 1: OR 1.49 (95% CI 0.78–2.84)
Intermediate exposure 2: OR 2.79 (95% CI 1.49–5.23)
Highest exposure: OR 1.24 (95% CI 0.51–2.99)
Low risk:
Selection: 3/4 stars, hospital controls
Comparability: 2/2 stars, low risk
Exposure: 3/3 stars, low risk
Total score: 8/9 stars, moderate quality.
Wang 1999 Reference category: lowest exposure
Oesophageal cancer
Highest exposure: OR 0.20 (95% CI 0.06‐0.67)
Other stomach cancer
Highest exposure: OR 0.28 (CIs NR)
Low risk:
Selection: 4/4 stars, low risk
Comparability: 2/2 stars, low risk
Exposure: 1/3 stars, no description of exposure ascertainment and non‐response rate different between cases and controls or NR
Total score: 7/9 stars, moderate quality.
Wang 2006 Reference category: lowest quartile
Oesophageal cancer
Highest exposure: OR 0.13 (95% CI 0.03‐0.62)
High risk:
Selection: 4/4 stars, low risk
Comparability: 0/2 stars, no information on confounders as smoking
Exposure: 2/3 stars, self‐reported exposure not within a structured interview or questionnaire.
Total score: 6/9 stars, low quality.
Wang 2007 Reference category: lowest exposure
Oesophageal cancer
Men
Highest exposure: OR 1.368 (95% CI 0.948‐1.975)
Women
Highest exposure: OR 0.257 (95% CI 0.070‐0.941)
Available analysis according green tea drinking duration (years)
Low risk:
Selection: 4/4 stars, low risk
Comparability: 1/2 stars, the study did not control for smoking.
Exposure: 2/3 stars, self‐reported exposure not within a structured interview or questionnaire.
Total score: 7/9 stars, moderate quality.
Wang 2012a Reference category: lowest exposure
Renal cancer
Highest exposure: OR 0.34 (95% CI 0.21–0.55)
High risk:
Selection: 3/4 stars, hospital controls
Comparability: 1/2 stars, the study did not control for smoking.
Exposure: 2/3 stars, non‐response rate different between cases and controls or NR
Total score: 6/9 stars, low quality.
Wang 2012b Reference category: lowest exposure
Multiple myeloma
Intermediate exposure 1: OR 0.94 (95% CI 0.52–1.72)
Intermediate exposure 2: OR 0.51 (95% CI 0.35‐0.73)
Highest exposure: OR 0.27 (95% CI 0.13–0.58)
Overall exposure: OR 0.38 (95% CI 0.27‐0.53)
Low risk:
Selection: 3/4 stars, hospital controls
Comparability: 1/2 stars, the study did not control for smoking.
Exposure: 3/3 stars, low risk
Total score: 7/9 stars, moderate quality.
Wang 2012c Reference category: lowest exposure
Pancreatic cancer
Men
Exposure assessment A
Highest exposure: OR 1.02 (95% CI 0.78‐1.35)
Exposure assessment B
Intermediate exposure 1: OR 0.99 (95% CI 0.71‐1.40)
Intermediate exposure 2: OR 1.38 (95% CI 0.91‐2.11)
Highest exposure: OR 0.91 (95% CI 0.65‐1.27)
Women
Exposure assessment A
Highest exposure: OR 0.68 (95% CI 0.48‐0.96)
Exposure assessment B
Intermediate exposure 1: OR 0.85 (95% CI 0.49–1.46)
Intermediate exposure 2: OR 0.64 (95% CI 0.37‐1.11)
Highest exposure: OR 0.56 (95% CI 0.32‐0.98)
Low risk:
Selection: 4/4 stars, low risk
Comparability: 2/2 stars, low risk
Exposure: 2/3 stars, non‐response rate different between cases and controls or NR
Total score: 8/9 stars, moderate quality.
Wang 2013a Reference category: lowest exposure
Breast cancer
Highest exposure: OR 0.65 (95% CI 0.44–0.97)
Low risk:
Selection: 3/4 stars, hospital controls
Comparability: 1/2 stars, the study did not control for smoking.
Exposure: 3/3 stars, low risk
Total score: 7/9 stars, moderate quality.
Wang 2013b Reference category: lowest exposure
Bladder cancer
Intermediate exposure: OR 0.82 (95% CI 0.61–1.11)
Highest exposure: OR 0.60 (95% CI 0.45–0.79)
Low risk:
Selection: 3/4 stars, hospital controls
Comparability: 2/2 stars, low risk
Exposure: 2/3 stars, non‐response rate different between cases and controls or NR
Total score: 7/9 stars, moderate quality.
Wang 2015 Reference category: lowest exposure
Stomach cancer
Exposure assessment A: green tea intake
Highest exposure: OR 0.72 (95% CI 0.32‐0.98)
Exposure assessment B: green tea consumption
Intermediate exposure: OR 0.87 (95% CI 0.43‐1.81)
Intermediate exposure: OR 0.66 (95% CI 0.36‐1.17)
Highest exposure: OR 0.53 (95% CI 0.23‐0.97)
Low risk:
Selection: 3/4 stars, hospital controls
Comparability: 2/2 stars, low risk
Exposure: 2/3 stars, non‐response rate different between cases and controls or not reported
Total score: 7/9 stars, moderate quality.
Wilkens 1996 Reference category: lowest exposure
Urinary tract cancer
Men
Intermediate exposure: OR 1.1 (95% CI 0.6‐1.9)
Highest exposure: OR 1.1 (95% CI 0.6‐2.3)
Women
Intermediate exposure: OR 0.8 (95% CI 0.3‐2.1)
Highest exposure: OR 0.9 (95% CI 0.3‐2.6)
Low risk:
Selection: 4/4 stars, low risk
Comparability: 2/2 stars, low risk
Exposure: 2/3 stars, non‐response rate different between cases and controls or NR
Total score: 8/9 stars, moderate quality.
Wu 2003 Reference category: lowest exposure
Breast cancer
Intermediate exposure: OR 0.74 (95% CI 0.52‐1.04)
Highest exposure: OR 0.61 (95% CI 0.40‐0.93)
Low risk:
Selection: 4/4 stars, low risk
Comparability: 2/2 stars, low risk
Exposure: 3/3 stars, low risk
Total score: 9/9 stars, high quality.
Wu 2009a Reference category: lowest exposure
Prostate cancer
Highest exposure: OR 0.52 (95% CI 0.28‐0.96)
Intermediate categories NR
High risk:
Selection: 2/4 stars, potential selection bias for cases and hospital controls
Comparability: 1/2 stars, the study did not control for smoking.
Exposure: 2/3 stars, non‐response rate different between cases and controls or NR
Total score: 5/9 stars, low quality.
Wu 2009b Reference category: lowest exposure
Oesophageal cancer
Dafeng (high risk area)
Highest exposure: OR 1.0 (95% CI 0.7‐1.3)
Ganyu (low risk area)
Highest exposure: OR 1.3 (95% CI 0.9‐1.7)
Low risk:
Selection: 3/4 stars, potential for selection bias in cases
Comparability: 2/2 stars, low risk
Exposure: 3/3 stars, low risk
Total score: 8/9 stars, moderate quality.
Xu 2007 Reference category: lowest exposure
Endometrial cancer
Highest exposure: OR 0.8 (95% CI 0.6‐0.9)
Low risk:
Selection: 4/4 stars, low risk
Comparability: 1/2 stars, the study did not control for smoking.
Exposure: 3/3 stars, low risk
Total score: 8/9 stars, moderate quality.
Xu 2013 Reference category: lowest exposure
Lung cancer
Highest exposure: OR 0.333 (95% CI 0.154 ‐0.720)
High risk:
Selection: 1/4 star, no description of cases, potential selection bias in cases, no description of controls
Comparability: 1/2 stars, the study did not control for smoking.
Exposure: 2/3 stars, non‐response rate different between cases and controls or NR
Total score: 4/9 stars, low quality.
Yan 2016 Reference category: lowest exposure
Oral cancer
Highest exposure: OR 0.58 (95% CI 0.42‐0.79)
Low risk:
Selection: 4/4 stars, low risk
Comparability: 2/2 stars, low risk
Exposure: 2/3 stars, non‐response rate different between cases and controls or NR
Total score: 8/9 stars, moderate quality.
Ye 1998 Reference category: lowest exposure
Stomach cancer
Highest exposure: OR 1.72 (95% CI 1.26‐2.36)
Low risk:
Selection: 4/4 stars, low risk
Comparability: 1/2 stars, the study did not control for smoking.
Exposure: 2/3 stars, self‐reported exposure not within a structured interview or questionnaire.
Total score: 7/9 stars, moderate quality.
Yu 1995 Reference category: lowest exposure
Stomach cancer
Highest exposure: OR 0.71 (95% CI 0.54‐0.93)
Highest exposure A: OR 0.76 (95% CI 0.57‐1.03)
Highest exposure B: OR 0.54 (95% CI 0.33‐0.88)
Subsite
Cardia
Highest exposure: OR 0.95 (95% CI 0.51‐1.77)
Highest exposure A: OR 0.94 (95% CI 0.47‐1.87)
Highest exposure B: OR 0.98 (95% CI 0.34‐2.89)
Pylori
Highest exposure: OR 0.29 (95% CI 0.13‐0.68)
Highest exposure A: OR 0.30 (95% CI 0.13‐0.73)
Highest exposure B: OR 0.24 (95% CI 0.05‐1.17)
Antrum
Highest exposure: OR 0.67 (95% CI 0.41‐1.08)
Highest exposure A: OR 0.79 (95% CI 0.48‐1.31)
Highest exposure B: OR 0.29 (95% CI 0.12‐0.71)
Other sites
Highest exposure: OR 0.82 (95% CI 0.41‐1.65)
Highest exposure A: OR 0.83 (95% CI 0.40‐1.73)
Highest exposure B: OR 0.76 (95% CI 0.15‐3.87)
Site unknown
Highest exposure: OR 0.69 (95% CI 0.23‐2.06)
Highest exposure A: OR 0.62 (95% CI 0.17‐2.18)
Highest exposure B: OR 0.87 (95% CI 0.15‐5.00)
Low risk:
Selection: 4/4 stars, low risk
Comparability: 2/2 stars, low risk
Exposure: 2/3 stars, non‐response rate different between cases and controls or NR
Total score: 8/9 stars, moderate quality.
Zhang 2002 Reference category: lowest exposure
Ovarian cancer
Intermediate exposure 1: OR 0.42 (95% CI 0.24‐0.73)
Intermediate exposure 2: OR 0.40 (95% CI 0.23‐0.70)
Highest exposure: OR= 0.43 (95% CI 0.30‐0.63)
Low risk:
Selection: 3/4 stars, hospital controls
Comparability: 2/2 stars, low risk
Exposure: 2/3 stars, self‐reported exposure not within a structured interview or questionnaire.
Total score: 7/9 stars, moderate quality.
Zhang 2007 Reference category: lowest exposure
Breast cancer
Intermediate exposure 1: 0.85 (95% CI 0.68–1.05)
Intermediate exposure 2: 0.92 (95% CI 0.75–1.12)
Intermediate exposure 3: 0.57 (95% CI 0.38–0.85)
Highest exposure: 0.57 (95% CI 0.47–0.69)
Low risk:
Selection: 3/4 stars, hospital controls
Comparability: 2/2 stars, low risk
Exposure: 3/3 stars, low risk
Total score: 8/9 stars, moderate quality.
Zhang 2008 Reference category: lowest exposure
Leukaemia
Exposure assessment A: intake of green tea
Highest exposure: OR 0.51 (95% CI 0.27–0.96)
Exposure assessment B: intake of green tea
Intermediate exposure: OR 0.40 (95% CI 0.14–1.14)
Highest exposure: OR 0.40 (95% CI 0.19–0.82)
Low risk:
Selection: 3/4 stars, hospital controls
Comparability: 2/2 stars, low risk
Exposure: 2/3 stars, self‐reported exposure not within a structured interview or questionnaire.
Total score: 7/9 stars, moderate quality.
Zheng 1993 Reference category: lowest exposure
Oral cancer
Highest exposure: HR 0.85 (95% CI 0.32–2.31)
Low risk:
Selection: 3/4 stars, hospital controls
Comparability: 2/2 stars, low risk
Exposure: 2/3 stars, self‐reported exposure not within a structured interview or questionnaire
Total score: 7/9 stars, moderate quality.
Zhong 2001 Reference category: lowest exposure
Lung cancer
Highest exposure: OR 0.65 (95% CI 0.45‐0.93) in nonsmokers
Highest exposure: OR 0.94 (95% CI 0.40‐2.22) in smokers
Low risk:
Selection: 4/4 stars, low risk
Comparability: 2/2 stars, low risk
Exposure: 2/3 stars, non‐response rate different between cases and controls or NR
Total score: 8/9 stars, moderate quality.