Ugai 2018.

Study characteristics
Methods	Cohort study in Japan
Participants	Participants: 140,420 (male/female: 68,722/71,698), with 61,595 from cohort 1 and 78,825 from cohort 2 and 95,807 (male/female: 45,937/49,870) participants with complete data in the present study. Inclusion criteria: aged 40‐59 years, from 5 Public Health Centre areas (Iwate, Akita, Nagano, Okinawa and Tokyo) for cohort 1 and aged 40‐69 years in cohort 2, from 6 Public Health Centre areas (Ibaraki, Niigata, Kochi, Nagasaki, Okinawa and Osaka), respondent at 5‐year follow‐up Parent cohorts Cohort 1: Japan Public Health Centre‐based Prospective Study (JPHC)‐I Cohort 2: Japan Public Health Centre‐based Prospective Study (JPHC)‐II Recruitment: from 1990 for cohort 1 and 1993/1994 for cohort 2
Interventions	N/A
Outcomes	Number of cases Outcome assessment: 31 December 2012 Acute myeloid leukaemia: 85 (male/female: 50/85) cases (Also reported 70 (male/female: 50/20) cases of myelodysplastic syndromes, not cancer)
Green tea in exposure categories	Exposure assessment: green tea drinking Lowest exposure: < 1 cup/d Intermediate exposure 1: 1‐2 cups/d Intermediate exposure 2: 3‐4 cups/d Highest exposure: ≥ 5 cups/d
Notes	Funding: National Cancer Center Research and Development Fund (23‐A‐31(toku) and 26‐A‐2; since 2011) and Ministry of Health, Labour and Welfare of Japan (from 1989‐2010; a Grant‐in‐Aid for Cancer Research) Statistical methods: Cox proportional hazard regression Variables controlled in analysis: age at baseline, sex, smoking status, alcohol consumption, BMI, occupation and study area Variables controlled by matching: ‐