NCT01496521.

Study name	Chemoprevention of esophageal squamous cell carcinoma (ESCC) with aspirin and tea polyphenols (CREAT)
Methods	RCT, quadruple‐blind
Participants	Adults aged 40‐60 years
Interventions	Intervention group A: aspirin 100 mg/d Intervention group B: tea polyphenols 100 mg/d Control group: placebo
Outcomes	Primary outcomes Occurrence of high‐grade dysplasia and invasive ESCC (at six months) Secondary outcomes Mortality of the participants (at 6 months and at 3 or 5 years later) Number of participants with adverse events (at 6 months and at 3 or 5 years later) Occurrence of high‐grade dysplasia and invasive ESCC (at 3 or 5 years later)
Starting date	January 2012
Contact information	Shu‐Tian Zhang, MD, Beijing Friendship Hospital Capital Medical University
Notes	Estimated study completion date: January 2013. No information on ClinicalTrials.gov