Diagnostic category | Biomarker probability of AD aetiology | Aβ (PET or CSF) | Neuronal injury (tau, FDG, sMRI) |
MCI‐core clinical criteria | Uninformative | Conflicting/indeterminant/untested | Conflicting/indeterminant/untested |
MCI due to AD – intermediate likelihood |
Intermediate | Positive | Untested |
MCI due to AD – high likelihood |
Highest | Untested Positive |
Positive Positive |
MCI – unlikely due to AD | Lowest | Negative | Negative |
Aβ: amyloid beta peptide; AD: Alzheimer's disease; CSF: cerebrospinal fluid; FDG: fluorodeoxyglucose; MCI: mild cognitive impairment; sMRI: structural magnetic resonance imaging; PET: positron emission tomography |