Wright 2013.
| Methods | Study design: cross‐sectional study (part of mixed method study, quantitative part is questionnaire survey) Instrument used to assess fatigue: Fatigue Scale for Adolescents Validated questionnaire: yes Cut‐off score or criterion for severe fatigue: score ≥ 31 Time points at which outcome data were collected: NA, cross‐sectional study Inclusion criteria: completed treatment for cancer during childhood or adolescence, aged 13 ‐ 18 years, ability to complete written questionnaire Exclusion criteria: antecedent neurological, developmental or genetic disorder |
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| Participants | Sample characteristics: N of participants original cohort: unknown; N of participants described study group: 48; N of participants study group of interest: 48; N of participants fatigue assessed: 48 Participant characteristics: Tumour type: leukaemia 66.6%, solid tumour 12.5%, lymphoma 18.7%, CNS tumour 2.1% Tumour stage: nm Age at diagnosis: mean 7.0 (SD 4.3; range 1.7 ‐ 14.6) Time since end of therapy: mean 6.9 years (SD 3.8; range 0.5 ‐ 13.0) Age at assessment: mean 16.0 years (SD 2.1; range 13 ‐ 18) F/M: 19/29 BMI: underweight 2.1%, healthy 74.5%, overweight 14.9%, obese 8.5% Race/ethnicity: nm Marital status: nm Highest completed education level: nm Employment: nm Physical activity level: Leisure Score Index of the GLTEQ mean 60.0 (SD 32.8) Sleeping problems: nm Psychosocial problems: nm Comorbidities/late effects: nm Genetic factors/mutations: nm |
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| Interventions | N of participants surgery: nm N of participants chemotherapy: nm N of participants radiotherapy: nm |
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| Outcomes | Severe fatigue: N of participants with severe fatigue: 6/48 (12.5%) Risk and associated factors: no analysis performed with fatigue as outcome |
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| Notes | Funding sources: nm Declaration of interest: nm |
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| Risk of bias | ||
| Bias | Authors' judgement | Support for judgement |
| Representative study group (selection bias) | Unclear risk | Size of original cohort is unclear |
| Adequate follow‐up assessment (attrition bias) | Low risk | Outcome was assessed for > 95% of the study group of interest |
| Blinded outcome assessor (detection bias) All outcomes | High risk | Outcome assessors were not blinded to the investigated determinant |
| Well‐defined study group (reporting bias) | High risk | Type of cancer treatment was not mentioned. Inclusion and exclusion criteria are described. |
| Well‐defined follow‐up (reporting bias) | Low risk | Length of follow‐up is mentioned |
| Well‐defined outcome severe fatigue (reporting bias) All outcomes | Low risk | The authors reported which instrument the used to assess fatigue and what they considered to be severe fatigue |