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. 2020 Mar 3;2020(3):CD012681. doi: 10.1002/14651858.CD012681.pub2

Liu 2018.

Methods Study design: cross‐sectional study
Instrument used to assess fatigue: Chinese version of Pediatric Patient‐Reported Outcomes Measurement Information System
Validated questionnaire: yes
Cut‐off score or criterion for severe fatigue: T‐score ≥ 70
Time points at which outcome data were collected: NA, cross‐sectional study
Inclusion criteria: children aged 8 ‐ 17 years, diagnosis of cancer either in treatment of in survivorshipa, able to speak and read Chinese, willing to participate in this study and have their parents' permission
Exclusion criteria: diagnosed psychiatric condition or a cognitive impairment (e.g. visual) that would interfere with participation, declined or had a parent declined to participate, were receiving end‐of‐life care (life expectancy < 6 weeks)
Participants Sample characteristics:
N of participants original cohort: 304; N of participants described study group: 272; N of participants study group of interest: 76b; N of participants fatigue assessed: 74
Participant characteristics:
Tumour type: leukaemia n = 62, lymphoma n = 7, solid tumours (brain tumours included) n = 5, others n = 2
Tumour stage: nm
Age at diagnosis: nm, based on age at assessment, the maximum age at diagnosis is 17 years
Time since end of therapy: nm
Age at assessment: mean 12.5 years (SD 2.85; range 8 ‐ 17)
F/M: nm
BMI: nm
Race/ethnicity: nm
Marital status: nm
Highest completed education level: nm
Employment: nm
Physical activity level: nm
Sleeping problems: nm
Psychosocial problems: nm
 Comorbidities/late effects: other health problem n = 7
Genetic factors/mutations: nm
Interventions N of participants surgery: nm
N of participants chemotherapy: nm
N of participants radiotherapy: nm
Outcomes Severe fatigue:
N of participants with severe fatigue: NDc
Risk and associated factors:
no analysis performed with fatigue as outcome
Notes Funding sources: This study was supported by the National Natural Science Foundation of China (project no. 71473262) and Intergovernmental International Cooperation Program of Science and Technology Commission of Shanghai Municipality, China (project no.18410711700)
Declaration of interest: The authors have no conflicts of interest to disclose
aDefinition of survivorship was requested through the corresponding author and is: who finished all the treatment and is in regular follow‐up?
bDescribed study group contains both participants on treatment and in survivorship; only the data of the in survivorship group is extracted.
cN of participants with severe fatigue is not reported in article. Additional information on severe fatigue was requested and not available.