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. 2020 Mar 3;2020(3):CD012681. doi: 10.1002/14651858.CD012681.pub2

Lowe 2016.

Methods Study design: cross‐sectional study (part of mixed‐methods study, quantitative part is questionnaire survey)
Instrument used to assess fatigue: POMS Fatigue subscale
 Validated questionnaire: yes
Cut‐off score or criterion for severe fatigue: NAa
Time points at which outcome data were collected: NA, cross‐sectional study
Inclusion criteria: diagnosed with cancer before age 18, being between 18 and 34 years oldb
Exclusion criteria: nm
Participants Sample characteristics:
N of participants original cohort: unknown; N of participants described study group: 104; N of participants study group of interest: 104; N of participants fatigue assessed: 104
Participant characteristics:
Tumour type: HL n = 24, NHL n = 9, Burkitts lymphoma n = 4, ALL n = 17, AML n = 3, blastoma n = 6, sarcoma n = 11, thyroid cancer n = 10, other n = 20
Tumour stage: nm
Age at diagnosis: nm
Time since diagnosis: mean 8.42 years (SD 5.73)
Age at assessment: mean 22.13 (SD 3.18)
F/M: 51/53
BMI: nm
Race: White n = 82, black n = 21, other n = 1
Ethnicity: Hispanic or Latino n = 5, not Hispanic or Latino n = 99
Marital status: married/living with partner n = 19, other n = 85
Highest completed education level: nm
Employment: employed n = 35, student n = 52, other n = 16c
Physical activity level: ≥ 5 days of aerobic PA a week n = 52, ≥ 2 days of strength training a week n = 31
Sleeping problems: nm
Psychosocial problems: POMS depression mean 4.36 (SD 5.05)
 Comorbidities: nm
Genetic factors/mutations: nm
Interventions N of participants chemotherapy: 86
 N of participants surgery: 81
 N of participants radiotherapy: 58
Outcomes Severe fatigue:
N of participants with severe fatigue: NDa
Risk and associated factors:
no analysis performed with fatigue as outcome
Notes Funding sources: Supported by the Georgia Cancer Coalition (PI: Berg), the National Cancer Institute (PI: Berg; 5K07CA139114), the Emory Egleston Children’s Research Center (PI: Esiashvili), and the Winship Cancer Institute Kennedy Survivorship Award (PI: Berg)
Declaration of interest: The authors declare that they have no competing interests.
aAuthors report fatigue on continuous scale. Additional information on severe fatigue was requested and not available.
bStudy author confirmed that the study population had no evidence of disease at time of the study
c Numbers do not add up to total N of described study group. Unclear what correct numbers were.