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. 2020 Mar 3;2020(3):CD012681. doi: 10.1002/14651858.CD012681.pub2

Meeske 2007.

Methods Study design: cross‐sectional study (retrospective questionnaire survey)
Instrument used to assess fatigue: 1 item, adapted from the National Comprehensive Cancer Network clinical practice guidelines that asks the child to rate his/her fatigue over the past 4 weeks
Validated questionnaire: yes
Cut‐off score or criterion for severe fatigue: NAa
Time points at which outcome data were collected: NA, cross‐sectional study
Inclusion criteria: cancer‐free, at least 5 years from diagnosis, off treatment for a minimum of 2 years, aged 8 ‐ 18 years
Exclusion criteria: incomplete data, Downs syndrome
Participants Sample characteristics:
N of participants original cohort: unknown; N of participants described study group: 86; N of participants study group of interest: 86; N of participants fatigue assessed: 77
Participant characteristics:
Tumour type: leukaemia n = 31, lymphoma n = 16, WT n = 10, brain tumour n = 12, retinoblastoma n = 4, neuroblastoma n = 3, rhabdomyosarcoma n = 5, germ cell tumour n = 3, hepatoblastoma n = 2
Tumour stage: nm
Age at diagnosis: mean 4.0 years (SD 2.6), based on age at assessment, the maximum age at diagnosis is 18 years
Time since end of therapy: mean 7.8 years (SD 2.5)
Age at assessment: mean 13.3 years (SD 2.9)
F/M: 35/51
BMI: nm
Race/ethnicity: White n = 29, Hispanic n = 41, other n = 16
Marital status: NA
Highest completed education level: NA
Employment: NA
Physical activity level: nm
Sleeping problems: nm
Psychosocial problems: nm
 Comorbidities/late effects: mild n = 36, moderate n = 27, severe n = 23
Genetic factors/mutations: nm
Interventions N of participants chemotherapy: 30
N of participants surgery: 4
N of participants surgery + radiotherapy: 2
N of participants surgery + chemotherapy: 22
N of participants chemotherapy + radiotherapy: 9
N of participants surgery, chemotherapy and radiotherapy: 19
N of participants cranial irradiation: 13
Outcomes Severe fatigue:
N of participants with severe fatigue: NDa
Risk and associated factors:
no analysis performed with fatigue as outcome
Notes Funding sources: Dr. Meeske is supported by a NCI training grant
Declaration of interest: nm
aAuthors report moderate to severe fatigue (score ≥ 4). Additional information on severe fatigue was requested and not available.