Meeske 2007.
Methods | Study design: cross‐sectional study (retrospective questionnaire survey) Instrument used to assess fatigue: 1 item, adapted from the National Comprehensive Cancer Network clinical practice guidelines that asks the child to rate his/her fatigue over the past 4 weeks Validated questionnaire: yes Cut‐off score or criterion for severe fatigue: NAa Time points at which outcome data were collected: NA, cross‐sectional study Inclusion criteria: cancer‐free, at least 5 years from diagnosis, off treatment for a minimum of 2 years, aged 8 ‐ 18 years Exclusion criteria: incomplete data, Downs syndrome |
Participants | Sample characteristics: N of participants original cohort: unknown; N of participants described study group: 86; N of participants study group of interest: 86; N of participants fatigue assessed: 77 Participant characteristics: Tumour type: leukaemia n = 31, lymphoma n = 16, WT n = 10, brain tumour n = 12, retinoblastoma n = 4, neuroblastoma n = 3, rhabdomyosarcoma n = 5, germ cell tumour n = 3, hepatoblastoma n = 2 Tumour stage: nm Age at diagnosis: mean 4.0 years (SD 2.6), based on age at assessment, the maximum age at diagnosis is 18 years Time since end of therapy: mean 7.8 years (SD 2.5) Age at assessment: mean 13.3 years (SD 2.9) F/M: 35/51 BMI: nm Race/ethnicity: White n = 29, Hispanic n = 41, other n = 16 Marital status: NA Highest completed education level: NA Employment: NA Physical activity level: nm Sleeping problems: nm Psychosocial problems: nm Comorbidities/late effects: mild n = 36, moderate n = 27, severe n = 23 Genetic factors/mutations: nm |
Interventions | N of participants chemotherapy: 30 N of participants surgery: 4 N of participants surgery + radiotherapy: 2 N of participants surgery + chemotherapy: 22 N of participants chemotherapy + radiotherapy: 9 N of participants surgery, chemotherapy and radiotherapy: 19 N of participants cranial irradiation: 13 |
Outcomes | Severe fatigue: N of participants with severe fatigue: NDa Risk and associated factors: no analysis performed with fatigue as outcome |
Notes | Funding sources: Dr. Meeske is supported by a NCI training grant Declaration of interest: nm aAuthors report moderate to severe fatigue (score ≥ 4). Additional information on severe fatigue was requested and not available. |