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. 2020 Mar 3;2020(3):CD012681. doi: 10.1002/14651858.CD012681.pub2

Zhang 2018.

Methods Study design: cross‐sectional study (part of St. Jude Lifetime Cohort study)
Instrument used to assess fatigue: Short Form 36 Vitality subscale
Validated questionnaire: yes
Cut‐off score or criterion for severe fatigue: NAa
Time points at which outcome data were collected: NA, cross‐sectional study
Inclusion criteria: diagnosis of childhood malignancy treated at St. Jude Childrens's Research Hospital, survival of ≥ 10 years from diagnosis, current age ≥ 18 years
Exclusion criteria: unreliable reporting for dietary intake
Participants Sample characteristics:
N of participants original cohort: unknown; N of participants described study group: 2480; N of participants study group of interest: 2480; N of participants fatigue assessed: 2480
Participant characteristics:
Tumour type: leukaemia n = 952, lymphoma n = 488, embryonal tumours n = 324, sarcoma n = 311, CNS tumour n = 229, other n = 172 b
Tumour stage: nm
Age at diagnosis: mean 8.3 years (SD 5.6)
Time since diagnosis: mean 24.1 years (SD 8.1)
Age at assessment: mean 32.3 years (SD 8.3)
F/M: 1205/1275
BMI: nm
Race/ethnicity: nm
Marital status: nm
Highest completed education level: nm
Employment: nm
Physical activity level: nm
Sleeping problems: nm
Psychosocial problems: nm
 Comorbidities/late effects: nm
Genetic factors/mutations: nm
Interventions N of participants surgery: nm
N of participants chemotherapy: nm
N of participants alkylating agents: 1567
N of participants anthracyclines: 1444
N of participants antimetabolites: 1320
 N of participants glucocorticoids: 1226
N of participants radiotherapy: 1487
N of participants head/neck radiotherapy only: 664
N of participants head/neck and chest radiotherapy: 158
N of participants head/neck, chest and abdomen/pelvis radiotherapy: 442
N of participants chest with or without abdomen/pelvis radiotherapy: 172
Outcomes Severe fatigue:
N of participants with severe fatigue: NDa
Risk and associated factors:
Several demographic and health‐related variables were investigated
Notes Funding sources: Supported by National Institutes of Health/National Cancer Institute grant 1R03CA199516‐01 (to Fang Fang Zhang), National Institutes of Health/National Cancer Institute grant U01CA194457 (to Melissa M. Hudson and Leslie L. Robison), and the American Lebanese Syrian Associated Charities.
Declaration of interest: The authors made no disclosures
Unclear if this study meets the inclusion criterion 'at least 90% of the participants were under 18 at diagnosis'
aAuthors report fatigue on continuous scale.
bAt different locations, different numbers are presented. The numbers that are presented here come from Table 1 of the study report.

ALL: acute lymphoblastoma leukaemia; AML: acute myeloid leukaemia; BMI: body mass index: F: female; HL: Hodgkins lymphoma; NHL: non‐Hodgkins lymphoma; M: male; PA: physical activity; POMS: Profile of mood states; SD: standard deviation