Zhang 2018.
Methods | Study design: cross‐sectional study (part of St. Jude Lifetime Cohort study) Instrument used to assess fatigue: Short Form 36 Vitality subscale Validated questionnaire: yes Cut‐off score or criterion for severe fatigue: NAa Time points at which outcome data were collected: NA, cross‐sectional study Inclusion criteria: diagnosis of childhood malignancy treated at St. Jude Childrens's Research Hospital, survival of ≥ 10 years from diagnosis, current age ≥ 18 years Exclusion criteria: unreliable reporting for dietary intake |
Participants | Sample characteristics: N of participants original cohort: unknown; N of participants described study group: 2480; N of participants study group of interest: 2480; N of participants fatigue assessed: 2480 Participant characteristics: Tumour type: leukaemia n = 952, lymphoma n = 488, embryonal tumours n = 324, sarcoma n = 311, CNS tumour n = 229, other n = 172 b Tumour stage: nm Age at diagnosis: mean 8.3 years (SD 5.6) Time since diagnosis: mean 24.1 years (SD 8.1) Age at assessment: mean 32.3 years (SD 8.3) F/M: 1205/1275 BMI: nm Race/ethnicity: nm Marital status: nm Highest completed education level: nm Employment: nm Physical activity level: nm Sleeping problems: nm Psychosocial problems: nm Comorbidities/late effects: nm Genetic factors/mutations: nm |
Interventions | N of participants surgery: nm N of participants chemotherapy: nm N of participants alkylating agents: 1567 N of participants anthracyclines: 1444 N of participants antimetabolites: 1320 N of participants glucocorticoids: 1226 N of participants radiotherapy: 1487 N of participants head/neck radiotherapy only: 664 N of participants head/neck and chest radiotherapy: 158 N of participants head/neck, chest and abdomen/pelvis radiotherapy: 442 N of participants chest with or without abdomen/pelvis radiotherapy: 172 |
Outcomes | Severe fatigue: N of participants with severe fatigue: NDa Risk and associated factors: Several demographic and health‐related variables were investigated |
Notes | Funding sources: Supported by National Institutes of Health/National Cancer Institute grant 1R03CA199516‐01 (to Fang Fang Zhang), National Institutes of Health/National Cancer Institute grant U01CA194457 (to Melissa M. Hudson and Leslie L. Robison), and the American Lebanese Syrian Associated Charities. Declaration of interest: The authors made no disclosures Unclear if this study meets the inclusion criterion 'at least 90% of the participants were under 18 at diagnosis' aAuthors report fatigue on continuous scale. bAt different locations, different numbers are presented. The numbers that are presented here come from Table 1 of the study report. |
ALL: acute lymphoblastoma leukaemia; AML: acute myeloid leukaemia; BMI: body mass index: F: female; HL: Hodgkins lymphoma; NHL: non‐Hodgkins lymphoma; M: male; PA: physical activity; POMS: Profile of mood states; SD: standard deviation