Table 2.
Insulin Sensitivity (S[I]) and Insulin Secretion (Φ) at Baseline and After 3 to 6 Months of Medical Weight Loss in Obese Subjects by Glucose Tolerance Category
| Normal Weight | Obese | ||||||
|---|---|---|---|---|---|---|---|
| NFG | NFG | IFG | T2DM | ||||
| Baseline | Baseline | 3-6 Mos | Baseline | 3-6 Mos | Baseline | 3-6 Mos | |
| N | 13 | 14 | 14 | 24 | 24 | 20 | 20 |
| S(I) (104dL/kg·min/μIU·mL) | 21.78 (14.91, 31.82) | 6.90 (4.61, 10.32) | 17.08* (11.15, 26.16) | 5.02 (3.77, 6.68) | 12.64* (9.36, 17.09) | 4.93 (3.13, 7.74) | 11.99* (9.03, 15.94) |
| Φ (μIU/mL per mg/dL) | 0.41 (0.33, 0.51) | 0.77 (0.60, 0.98) | 0.44* (0.32, 0.61) | 0.78 (0.66, 0.90) | 0.48* (0.39, 0.59) | 0.51 (0.39, 0.66) | 0.42 (0.34, 0.53) |
Abbreviations: IFG, impaired fasting glucose; mos, months; NFG, normal fasting glucose; T2DM, type 2 diabetes.
*P < 0.001 for ratio of geometric means at 3-to-6 months vs. baseline