. Author manuscript; available in PMC: 2020 Jun 1.

Published in final edited form as: Eur Neuropsychopharmacol. 2019 Apr 10;29(6):740–755. doi: 10.1016/j.euroneuro.2019.03.013

Table 2.

Ketamine pharmacokinetics in the hippocampus of male and female preweanling, adolescent, and adult rats injected with 80 mg/kg ketamine (i.p.).

Age - Sex	Ketamine
	C_max	T_max	Lambda_Z	t_1/2	AUC
PD 20 (n = 8 per group)
Male	64.40 (1.9)	9.38 (1.8)	0.015 (.0010)	47.37 (3.0)	3784.66 (309.5)
Female	64.26 (3.5)	5.62 (0.6)	0.013 (.0008)	53.56 (3.3)	3565.28 (136.0)
PD 30 (n = 4 per group)
Male	55.50 (3.7)	7.50 (1.4)	0.028 (.0040)^bc	26.28 (4.6)^de	1731.62 (284.9)^b
Female	52.89 (3.0)	8.75 (1.2)	0.025 (.0154)	48.16 (6.5)^de	2712.99 (146.5)^a
PD 40 (n = 8 per group)
Male	41.93 (4.4)^b	8.75 (2.0)	0.028 (.0016)^bc	25.71 (1.6)^de	1242.63 (85.0)^b
Female	66.24 (4.4)^a	7.14 (1.0)	0.015 (.0009)^a	47.90 (2.5)^de	2791.13 (208.2)^a
PD 80 (n = 8–9 per group)
Male	32.17 (3.9)^b	5.94 (2.0)	0.016 (.0015)	47.46 (4.6)	901.42 (104.2)^b
Female	56.57 (3.5)^a	5.31 (0.7)	0.013 (.0010)	56.40 (4.0)	3054.88 (224.2)^a

Note: C_max, maximum concentration of ketamine (μg/g); T_max, time of maximum concentration (min after injection); Lambda_Z, elimination constant (1/min); t_1/2, ketamine half-life (min); AUC, area under the curve (0–360 min).

Significantly different from male rats of the same age.

Significantly different from PD 20 rats of the same sex.

Significantly different from PD 80 rats of the same sex.

Significantly different from PD 20 rats (Age main effect).

Significantly different from PD 80 rats (Age main effect).