Table 5.

Criterion Values and Coordinates of the ROC Curve of Serum Concentration of CC16 for Distinguishing Between COPD and Healthy People

Criterion	Sensitivity	95% CI	Specificity	95% CI	+LR	95% CI	−LR	95% CI
≤70.22	11.22	5.7–19.2	100.00	92.6–100.0			0.89
≤85.21	37.76	28.2–48.1	95.83	85.7–99.5	9.06	7.0–11.8	0.65	0.2–2.5
≤88.12	39.80	30.0–50.2	87.50	74.8–95.3	3.18	2.4–4.2	0.69	0.3–1.5
≤93.56	47.96	37.8–58.3	83.33	69.8–92.5	2.88	2.3–3.7	0.62	0.3–1.2
≤97.12	55.10	44.7–65.2	77.08	62.7–88.0	2.40	1.9–3.0	0.58	0.3–1.0
≤99.32*	65.31	55.0–74.6	75.00	60.4–86.4	2.61	2.1–3.2	0.46	0.3–0.8
≤103.11	67.35	57.1–76.5	64.58	49.5–77.8	1.90	1.5–2.4	0.51	0.3–0.8
≤107.22	73.47	63.6–81.9	64.58	49.5–77.8	2.07	1.6–2.6	0.41	0.2–0.7
≤114.25	85.71	77.2–92.0	47.92	33.3–62.8	1.65	1.2–2.2	0.30	0.2–0.5
≤125.12	92.86	85.8–97.1	16.67	7.5–30.2	1.11	0.6–2.1	0.43	0.2–0.9
≤135.22	97.96	92.8–99.8	6.25	1.3–17.2	1.04	0.3–3.1	0.33	0.08–1.3
≤159	100.00	96.3–100.0	0.00	0.0–7.4	1.00

Note:* The threshold for differentiating COPD patients from healthy individuals.

Abbreviations: ROC, receiver operating characteristic curve; CC16, Clara cell secretory protein; COPD, chronic obstructive pulmonary disease; 95% CI, 95% confidence; +LR, positive likelihood ratio; −LR, negative likelihood ratio.