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. Author manuscript; available in PMC: 2021 Mar 1.
Published in final edited form as: FASEB J. 2020 Jan 23;34(3):4283–4292. doi: 10.1096/fj.201902264RR

Figure 2. Effects of in vivo hypoxia and ex vivo L-NAME incubation on uterine artery troglitazone (TGZ)-induced vasorelaxation.

Figure 2.

Uterine arteries were preconstricted with PE prior to TGZ or L-NAME exposure. A) Concentration response curves to troglitazone (TGZ; 0.1–100 μmol) for uterine arteries with pre-incubation with L-NAME (30 min; 10 μmol) or control (CON) in uterine arteries preconstricted with PE from normoxic (NORM) or hypoxic (HX) mice. HX and NORM dams are represented by open squares and solid circles, respectively. Curves generated without or with L-NAME are represented by solid or dashed lines, respectively. B) The maximum vasodilator response to TGZ (expressed as the % PE-induced constriction achieved by TGZ or TGZ + L-NAME) was blunted by L-NAME in normoxic dams. C) Overall sensitivity to TGZ as represented by area under the curve. Data are presented as means ± SEM and compared by 2-way ANOVA with differences between groups identified by Sidak’s multiple comparisons; n = 10 NORM CON, 10 NORM + L-NAME, 9 HX CON, 9 HX + L-NAME.