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. Author manuscript; available in PMC: 2021 Mar 1.
Published in final edited form as: FASEB J. 2020 Jan 23;34(3):4283–4292. doi: 10.1096/fj.201902264RR

Figure 3. Effects of in vivo hypoxia and ex vivo troglitazone on the uterine artery contractile response to endothlelin-1 (ET-1).

Figure 3.

A) Concentration response curves to ET-1 (0.1–30 nmol/L) with 20 min pre-incubation with troglitazone (TGZ; 1 μmol/L) or control (CON) in uterine arteries from normoxic (NORM) or hypoxic (HX) mice. B) Maximum contractile response to ET-1 was higher in HX dams, and TGZ blunted the maximal response in NORM and HX dams. C) Overall sensitivity to ET-1 as represented by area under the curve. Data are presented as means ± SEM and compared by 2-way ANOVA with differences between groups identified by Sidak’s multiple comparisons; n = 11 NORM CON, 11 NORM + TGZ, 15 HX CON, 14 HX + TGZ.