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. Author manuscript; available in PMC: 2021 Mar 1.
Published in final edited form as: J Cardiovasc Pharmacol. 2020 Mar;75(3):211–221. doi: 10.1097/FJC.0000000000000778

Fig.5.

Fig.5.

Effect of SDX on Phe contraction in stretched veins. Rat IVC rings were equilibrated under 0.5g-resting tension and a control concentration-contraction curve to Phe (10−9–10−5M) was elicited. The IVC rings were washed in Krebs then subjected to extended 2g-stretch for 18h in the absence or presence of SDX (0.5mg/ml), and another concentration-contraction curve to Phe was elicited. The Phe response was presented in mg/mg tissue (A), as % of control 96mM-KCl contraction (B), as % of maximal Phe contraction (C), or best fitted using the least square method and the cumulative Phe pEC50 was calculated (D). Data represent means±SEM, n=8. * Significantly different (P<0.05) in stretched veins versus control veins under 0.5g-resting tension. # Significantly enhanced (P<0.05) in veins under stretch+SDX versus veins under stretch alone. ‡ Significantly enhanced (P<0.05) in veins under stretch+SDX versus control veins under 0.5g-resting tension.