Table 3.
Predictive factors for the presence of residual disease after re-resection in patients with incidental gallbladder cancer (n = 102)
| Characteristic | Univariable logistic regression | Multivariable logistic regression | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | p value | HR | 95% CI | p value | |
| Tumor differentiation grade | ||||||
| Well | 1 | c | ||||
| Moderate | 2.49 | 0.62–9.96 | 0.197 | c | ||
| Poor | 5.03 | 1.17–21.59 | 0.030 | c | ||
| Unknown | 1.56 | 0.26–9.47 | 0.632 | c | ||
| Pathological N stage | ||||||
| 0 | 1 | 1 | ||||
| 1/2 | 25.00 | 2.36–264.80 | 0.008 | 23.00 | 1.57–337.44 | 0.022* |
| Unknown | 1.00 | 0.284–3.53 | 1.000 | 1.053 | 0.14–4.18 | 0.763 |
| Pathological T stage | ||||||
| T1 | 1 | 1 | ||||
| T2 | 0.93 | 0.20–5.44 | 0.966 | 1.22 | 0.18–8.52 | 0.838 |
| T3/Tx | 11.60 | 3.04–131.73 | 0.002 | 25.33 | 2.98–215.69 | 0.003* |
| Time since index surgery (days) | 1.00 | 0.99–1.01 | 0.788 | |||
| Radicality primary resection | ||||||
| R0 | 1 | c | ||||
| R1/R2 | 4.80 | 1.97–11.70 | 0.001 | c | ||
| Unknown | 1.14 | 0.11–11.87 | 0.911 | c | ||
| Socioeconomic status (deciles) | 1.03 | 0.88–1.19 | 0.743 | |||
| Hospital of diagnosis | ||||||
| Community | 1 | |||||
| Academic | 0.21 | 0.03–1.73 | 0.146 | |||
| Lymphovascular invasion (yes)a | 4.25 | 1.77–10.18 | 0.001 | c | ||
| Perineural invasion (yes)b | 3.18 | 1.25–8.09 | 0.015 | c | ||
All variables with p < 0.10 on univariable analysis were entered into the multivariable model
aMissing values in 10 cases
bMissing values in 13 cases
cNot significant during forward selection
*p value < 0.005