Table 4.
The cell types and tissue enrichment of the top 10 human serum sEV miRNAs.
| miRNA_id | he_TPM | hd_TPM | Fold-change | Cell or Tissue enriched |
|---|---|---|---|---|
| hsa-miR-486-5p | 360870.0 | 325558.5 | 1.1 | mature-erythrocyte |
| hsa-miR-92a-3p | 44958.0 | 10094.5 | 4.5 | mature-erythrocyte, brain pfc, lung, CD4 + Tcell, monocyte-derived-macrophage |
| hsa-miR-451a | 24460.0 | 3169.0 | 7.7 | lung, adipose, skin, breast, peripheral bmc |
| hsa-miR-423-5p | 23392.0 | 28184.0 | 0.8 | testicular germ, pancreatic beta cell, pancreatic islet |
| hsa-miR-191-5p | 8452.0 | 3218.0 | 2.6 | brain pfc, brain sfg, monocyte-derived-macrophage |
| hsa-let-7b-5p | 5221.5 | 1320.5 | 4.0 | testicular germ, skin, colon, kidney |
| hsa-miR-26a-5p | 5138.0 | 633.0 | 8.1 | brain sfg |
| hsa-miR-10b-5p | 3795.5 | 703.5 | 5.4 | adipose, skin, kidney, colon |
| hsa-miR-10a-5p | 2990.0 | 465.5 | 6.4 | lung, colon, skin, adipose |
| hsa-miR-125b-5p | 2983.5 | 986.0 | 3.0 | prostate, ventricular-myocardium, lung, primary fibroblast, gastric |
Note: brain pfc, brain prefrontal cortex; brain sfg, brain superior frontal gyrus; peripheral bmc, peripheral blood mononuclear cells.; h, human; sEV, small extracellular vesicle; e, serum small extracellular vesicle; d, small extracellular vesicle-depleted serum; TPM, transcripts per million reads. The TPM values provided here are the average of two biological replicates.