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. 2020 Mar 6;10:4173. doi: 10.1038/s41598-020-61154-4

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Target regions and distances from ATG codon to the PTC influence the efficiency of mutant mRNA decay (mutant mRNA levels/WT mRNA levels). The Mu/WT ratios of mRNA expression levels for target gene in each tissue are shown. (a) The efficiencies of mRNA decay are differentially influenced by the target regions: Proximity to ATG (<110 bp), far from ATG (>110 bp). (b) The influence of distance from the ATG codon to the PTC on the efficiency of mRNA decay. PTCs are located within 150 bp downstream from ATG (<150) or at distance of over 150 bp from ATG (>150). (c) The influence of the number of deleted nucleotides on the efficiency of mRNA decay. The Mu/WT ratios of mRNA expression levels for the target genes in each tissue are shown for each range of deletion lengths. Deletion lengths are less than 10 bp (<10 bp), from 10 to 30 bp (10~30), or over 30 bp (>30). (d) The distance from the PTC to the next EJC influences the efficiency of mRNA decay. PTCs are located within 100 bp upstream from the next EJC (<100) or at a distance of over 100 bp from the next EJC (>100). The central lines represent the median gene expression ratio. p values are from two-tail Mann-Whitney tests. Mu, Mutant.