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. 2020 Mar 6;11:1228. doi: 10.1038/s41467-020-15051-z

Fig. 3. Inhibition of SQR with Qp site inhibitor TTFA effectively sensitizes resistant MM to venetoclax.

Fig. 3

a−h SQR inhibition with TTFA (100 μM) sensitizes indicated myeloma cell lines to venetoclax more effectively than inhibition of SDHA with 3-NPA (1000 μM except for RPMI-8226 treated with 250 μM) upon cotreatment with indicated doses of venetoclax for 24 h. Cell viability assessed by AnnexinV/DAPI staining. n = 3 independent experiments. Data are presented as mean values ± SEM. i SQR, j SDH and k CS activities were evaluated demonstrating selective inhibition of SQR activity upon 24 h TTFA treatment. Data are presented as mean values ± SEM. p values are calculated using a two-tailed unpaired Student’s t test. Data presented are from an n = 3 ± SEM. Source data are provided as a source data file.