Table 1.
Patient characteristics of the cohort
| Parameter | Total | Recurrence | Mortality | |||||
|---|---|---|---|---|---|---|---|---|
| No. | (%) | No. | (%) | p | No. | (%) | p | |
| Total | 416 | (100) | 79 | (19) | 135 | (32) | ||
| Age (year) | ||||||||
| < 70 | 173 | (42) | 31 | (18) | 0.638 | 32 | (18) | < 0.001 |
| > 70 | 243 | (58) | 48 | (20) | 103 | (42) | ||
| Sex | ||||||||
| Male | 208 | (50) | 37 | (18) | 0.532 | 71 | (34) | 0.464 |
| Female | 208 | (50) | 42 | (20) | 64 | (31) | ||
| ASA | ||||||||
| 1 | 72 | (17) | 11 | (15) | 0.653 | 12 | (17) | < 0.001 |
| 2 | 187 | (45) | 36 | (19) | 50 | (27) | ||
| 3–4 | 157 | (38) | 32 | (20) | 73 | (46) | ||
| Surgery | ||||||||
| Elective | 341 | (82) | 51 | (15) | < 0.001 | 99 | (29) | 0.001 |
| Emergency | 75 | (18) | 28 | (37) | 36 | (48) | ||
| Sidedness | ||||||||
| Right | 230 | (55) | 50 | (22) | 0.112 | 81 | (35) | 0.180 |
| Left | 186 | (45) | 29 | (16) | 54 | (29) | ||
| pT | ||||||||
| pT1 | 35 | (8) | 0 | (0) | 0.001 F | 6 | (17) | < 0.001F |
| pT2 | 37 | (9) | 4 | (11) | 11 | (30) | ||
| pT3a | 49 | (12) | 7 | (14) | 11 | (22) | ||
| pT3b | 102 | (25) | 16 | (16) | 27 | (26) | ||
| pT3c | 77 | (19) | 16 | (21) | 21 | (27) | ||
| pT3d | 39 | (9) | 12 | (31) | 19 | (49) | ||
| pT3NA | 1 | (0) | 0 | (0) | 1 | (100) | ||
| T4a | 49 | (12) | 17 | (35) | 26 | (53) | ||
| T4b | 27 | (6) | 7 | (26) | 13 | (48) | ||
| pN | ||||||||
| pN0 | 226 | (54) | 20 | (9) | < 0.001 | 56 | (25) | 0.001 |
| pN1a | 53 | (13) | 13 | (25) | 21 | (40) | ||
| pN1b | 56 | (13) | 12 | (21) | 20 | (36) | ||
| pN1c | 14 | (3) | 2 | (14) | 4 | (29) | ||
| pN2a | 34 | (8) | 16 | (47) | 14 | (41) | ||
| pN2b | 33 | (8) | 16 | (48) | 20 | (61) | ||
| Sampled nodes | ||||||||
| < 12 | 38 | (9) | 3 | (8) | 0.067 | 10 | (26) | 0.397 |
| ≥ 12 | 378 | (91) | 76 | (20) | 125 | (33) | ||
| TD | ||||||||
| No | 337 | (81) | 57 | (17) | 0.056 | 103 | (31) | 0.233 |
| Yes | 56 | (13) | 17 | (30) | 23 | (41) | ||
| Malignancy grade | ||||||||
| Low | 350 | (84) | 59 | (17) | 0.011 | 107 | (31) | 0.059 |
| High | 66 | (16) | 20 | (30) | 28 | (42) | ||
| Mucinous | ||||||||
| No | 338 | (81) | 66 | (20) | 0.158 | 108 | (32) | 0.691 |
| Yes | 63 | (15) | 13 | (21) | 23 | (37) | ||
| Vascular invasion | ||||||||
| No | 291 | (70) | 35 | (12) | < 0.001 | 82 | (28) | 0.005 |
| Yes | 112 | (27) | 41 | (37) | 45 | (40) | ||
| Perineural invasion | ||||||||
| No | 343 | (82) | 51 | (15) | < 0.001 | 98 | (29) | 0.001 |
| Yes | 52 | (13) | 23 | (44) | 26 | (50) | ||
| CEA (ng/ml) | ||||||||
| Preoperative | ||||||||
| < 5 | 195 | (47) | 30 | (15) | 0.207 | 49 | (25) | 0.010 |
| > 5 | 110 | (26) | 25 | (23) | 41 | (37) | ||
| Postoperative | ||||||||
| < 5 | 220 | (53) | 36 | (16) | 0.001 | 59 | (27) | 0.021 |
| > 5 | 23 | (6) | 11 | (48) | 11 | (48) | ||
| CRP (mg/l) | ||||||||
| Preoperative | ||||||||
| < 10 | 211 | (51) | 35 | (17) | 0.002 | 60 | (28) | 0.084 |
| > 10 | 136 | (33) | 38 | (28) | 54 | (40) | ||
| Postoperative | ||||||||
| < 10 | 204 | (49) | 36 | (18) | 0.505 | 59 | (29) | < 0.001 |
| > 10 | 48 | (12) | 12 | (25) | 28 | (58) | ||
| Adjuvant chemotherapy | ||||||||
| No | 268 | (64) | 35 | (13) | < 0.001 | 96 | (36) | 0.048 |
| Yes | 148 | (36) | 44 | (30) | 39 | (26) | ||
Number of cases for each category of the variable and percent of cases in each category. (# by cohort size). Outcomes recurrence and mortality reported with number of cases and the percent within each category. Cases with missing data not reported. P values are calculated with Pearson’s χ2 test or the Fisher’s exact test (F)