Table 2.
Subgroup analyses of associations between miR-21 expression and OS.
| Subgroup | Number of Studies | Number of Patients | Pooled model | Pooled HR (95% CI) | Heterogeneity | Publication bias (P-value) | ||
|---|---|---|---|---|---|---|---|---|
| I2 (%) | P-value | Begg’s test | Egger’s test | |||||
| All | 8 | 1059 | random | 1.91 (1.34, 2.73) | 82 | <0.001 | 0.216 | 0.236 |
| Locations | ||||||||
| Asian | 5 | 509 | random | 2.37 (1.68, 3.35) | 52 | 0.083 | 0.624 | 0.719 |
| Non-Asian | 3 | 640 | fixed | 1.25 (1.07, 1.45) | 0 | 0.400 | 0.602 | 0.164 |
| Method | ||||||||
| qRT-PCR | 7 | 960 | random | 1.99 (1.31, 3.01) | 85 | <0.001 | 0.293 | 0.262 |
| ISH | 1 | 189 | — | 1.55 (1.00, 2.38) | — | — | — | — |
| Cut-off value | ||||||||
| Median | 4 | 705 | random | 2.09 (1.41, 3.11) | 67 | 0.028 | 0.497 | 0.195 |
| Mean | 3 | 409 | random | 1.51 (1.00, 2.27) | 63 | 0.068 | 0.117 | 0.087 |
| 1.5-fold | 1 | 35 | — | 2.66 (1.02, 6.93) | — | — | — | — |
| Follow-up (month) | ||||||||
| ≤60 | 1 | 152 | — | 3.17 (2.40, 4.19) | — | — | — | — |
| >60 | 7 | 997 | fixed | 1.36 (1.19, 1.56) | 43 | 0.107 | 0.051 | 0.000 |
| Adjustment variables | ||||||||
| Yes | 5 | 848 | random | 1.78 (1.15, 2.75) | 89 | <0.001 | 0.624 | 0.447 |
| No | 3 | 211 | fixed | 2.22 (1.37, 3.59) | 0 | 0.433 | 0.117 | 0.165 |