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. 2020 Mar 6;10:4233. doi: 10.1038/s41598-020-60903-9

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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ChREBP mRNA and protein levels positively correlate to colon malignancy. (A) Relative mRNA level of ChREBP normalized to 18s in 20 pairs of colon cancer tissue and adjacent normal tissue. (B) Relative mRNA level of ChREBP normalized to 18s in normal, early and late clinically staged colon cancer tissue. (C) ChREBP protein expression in normal, early and late clinically staged colon cancer tissues. Relative mRNA levels of FAS (D), ELOVL6 (E) and SCD1 (F) normalized to 18s in early and late clinically staged colon cancer tissue. (G) ChREBP immunohistochemistry in healthy and malignant colon sections. The strong ChREBP positive staining in malignant colon (b) compared with an mild staining in adjacent normal colon tissue (a) in the same patient; c, a negative immunohistochemical staining control, which was incubated with PBS instead of preliminary antibody; d, healthy colon tissue; e, clinical stages I and II colon cancer tissue; f, clinical stages III and IV colon cancer tissue. Photos were taken under the magnification of 200×. Scale bar = 30 μm. *p < 0.05; **p < 0.01; ***p < 0.001.