Figure 1.

Effects of insulin resistance on body weight, blood glucose, and glycated Hb. (a) Body weight (g), (b) blood glucose (mM), (c) Endpoint HbA1c (%), (d) plasma insulin (represented as fold compared to AnxA1 ^+/+ sham group), and glucose tolerance, both (e) over time and (f) AUC in sham AnxA1 ^+/+ (n = 10), sham AnxA1 ^−/− (n = 7), insulin‐resistant (InsRes) AnxA1 ^+/+ (n = 6), and insulin‐resistant AnxA1 ^−/− (n = 14) male mice. Values are mean ± SEM. ^* P < .05, significantly different from sham AnxA1 ^+/+, ^# P ≤ .05, significantly different from AnxA1 ^−/− sham mice. (a), (b), and (e) were analysed using repeated‐measures two‐way ANOVA with Bonferroni post hoc analysis. (c), (d), and (f) were analysed using a two‐way ANOVA with Fisher's LSD post hoc analysis