Figure 4.

Effects of insulin deficiency on body weight, blood glucose, and glycated Hb. (a) Body weight (g) and (b) blood glucose (mM) measures during treatment in sham (circles) and insulin‐deficient (InsDef;) AnxA1 ^+/+ and AnxA1 ^−/− male mice. (c) Endpoint glycated haemoglobin (HbA1c, %) and (d) plasma insulin levels were also determined (represented as fold compared to AnxA1 ^+/+ sham group). Sham AnxA1 ^+/+ (n = 10), sham AnxA1 ^−/− (n = 7), insulin‐deficient AnxA1 ^+/+ (n = 6), and insulin‐deficient AnxA1 ^−/− ( n = 12) male mice. Values are mean ± SEM. *P < .05, significantly different from sham AnxA1 ^+/+, ^# P < .05, significantly different from AnxA1 ^−/− sham mice. (a) and (b) were analysed using repeated‐measures two‐way ANOVA with Bonferroni post hoc analysis. (c) and (d) were analysed using a two‐way ANOVA with Fisher's LSD post hoc analysis