Table 2.

Summary of the phenotypes of insulin‐resistant and insulin‐deficient AnxA1 ^+/+ and AnxA1 ^−/− male mice compared with AnxA1 ^+/+ sham controls

	Insulin‐resistant study			Insulin‐deficient study
	AnxA1 −/− sham	AnxA1 +/+ InsRes	AnxA1 −/− InsRes	AnxA1 −/− sham	AnxA1 +/+ InsDef	AnxA1 −/− InsDef
Body weight	↔	↔	↔	↔	↓	↓↓
Blood glucose	↔	↑	↑	↔	↑↑	↑↑
GTT	↔	↑	↑	ND	ND	ND
HbA1c	↔	↑	↔	↔	↑	↑
Plasma insulin	↔	↔	↔	↓	↓	↓
Systolic BP	↔	↔	↔	↔	↓	↓
Heart rate	↔	↔	↑	↔	↔	↔
Vascular Remodelling	None	Outward (hypertrophic)	None	None	Outward (hypertrophic)	Outward (eutrophic)
Circumferential stiffness	↔	↔	↔	↔	↔	↓
Volume compliance	↓	↔	↓	↔	↑	↑
Arterial lengthening	↓	↓	↓	↔	↑	↔

Abbreviations: GTT, glucose tolerance test; HbA1c, glycated Hb; ND, not determined.