Figure 2.

Pharmacological manipulation of the activity of Wnt/β‐catenin signaling pathway. High‐throughput screening identified chemical probes that target tankyrase (TNKS), porcupine (Porcn), casein kinase 1α (CK1α), β‐catenin‐TCF interaction, transcriptional co‐activators of TCF, and β‐catenin degradation (see Table 1 for more details and references). β‐TrCP, β‐transducin repeat containing E3 ubiquitin protein ligase; APC, APC regulator of WNT signaling pathway (adenomatous polyposis coli); CBP, CREB‐binding protein; CK1, casein kinase‐1; Dvl, Dishevelled segment polarity protein; GSK‐3, glycogen synthase kinase‐3; LEF, lymphoid enhancer binding factor; LRP, LDL receptor related protein; TCF7L2, transcription factor 7 like 2; TNKS, tankyrase