Table 4.
Selected results from the top 50 IPA function and disease categories of RIS hearts filtered for tissue specificity and metabolic functions.
| Categories | Diseases or Functions Annotation | p-value | Molecules |
|---|---|---|---|
| Cell Signaling, Post-Translational Modification, Protein Synthesis | Assembly of Respiratory chain complex I | 0.0001 | NDUFA10,NDUFA8,NDUFA9,NDUFB8,NDUFB9,NDUFS7 |
| Cellular Assembly and Organization | Accumulation of mitochondria | 0.0006 | MAP1S,TARDBP,TFRC |
| Cellular Movement, Immune Cell Trafficking | Migration of inflammatory leukocytes | 0.001 | PLAUR,PPIA |
| Molecular Transport, Nucleic Acid Metabolism, Small Molecule Biochemistry | Quantity of NADH | 0.003 | NQO1,SLC27A1 |
| Inflammatory Response | Inflammation of lesion | 0.006 | CD14, GJA1 |
| Cellular Development, Cellular Growth and Proliferation, Connective Tissue Development and Function, Hematological System Development and Function, Lymphoid Tissue Structure and Development, Tissue Development | Proliferation of peripheral T lymphocyte | 0.006 | TFRC, CSNK1A1 |
| Metabolic Disease | Mitochondrial disorder | 0.007 | DLD,HMGCS2,NDUFA10,NDUFA9,NDUFB9,NDUFS3,NDUFS7,SLC25A4 |
| Cardiovascular System Development and Function, Organ Morphology | Dilation of heart ventricle | 0.009 | CAMK2D,CAST,LMNA |
| Cell-mediated Immune Response, Lymphoid Tissue Structure and Development | Frequency of T lymphocytes | 0.009 | PTPN6, ZEB2, NOTCH2 |
| Cardiovascular Disease, Hereditary Disorder, Organismal Injury and Abnormalities, Skeletal and Muscular Disorders | Arrhythmogenic right ventricular dysplasia familial 9 | 0.01 | LMNA,MYH7 |
| Cellular Movement, Hematological System Development and Function, Immune Cell Trafficking, Inflammatory Response | Chemotaxis of peripheral blood monocytes | 0.01 | PLAUR,PPIA |
| Cellular Assembly and Organization | Sliding of myofilaments | 0.01 | MYH7,MYL6 |
Using IPA, over 500 disease and function categories were identified from DE proteins in RIS hearts. Top results relating to cardiovascular disease, metabolic disease and inflammation were identified in RIS hearts. Significantly down-regulated proteins are highlighted in blue