Table 1.

Effect of high-risk nsSNPs in GJA3 gene on post translational modification sites predicted by ModPred tool

Residue	Modification	Score	Confidence	High-risk nsSNP
G2	N-terminal acetylation	0.53	Low	G2D, G2S
	Proteolytic cleavage	0.52	Low
D3	Proteolytic cleavage	0.7	Medium	D3H, D3Y
S5	Proteolytic cleavage	0.59	Low	S5R
H17	Proteolytic cleavage	0.51	Low	H17R
T19	Amidation	0.97	High	T19M
R33	Proteolytic cleavage	0.67	Low	R33H, R33P, R33L
E42	Proteolytic cleavage	0.79	Medium	E42A
D47	Proteolytic cleavage	0.62	Low	D47N, D47Y
S50	Proteolytic cleavage	0.75	Medium	S50P
D67	Proteolytic cleavage	0.8	Medium	D67N
R76	Proteolytic cleavage	0.55	Low	R76H, R76G
G94	Proteolytic cleavage	0.67	Low	G94A
H98	Proteolytic cleavage	0.92	High	H98Q
R101	Proteolytic cleavage	0.95	High	R101P
G143	Proteolytic cleavage	0.78	Medium	G143R, G143E
R147	Proteolytic cleavage	0.75	Medium	R147Q, R147W
T148	Proteolytic cleavage	0.55	Low	T148I
K156	SUMOylation	0.52	Low	K156Q
G172	Proteolytic cleavage	0.52	Low	G172D, G172S
P187	Hydroxylation	0.57	Low	P187L, P187S
P197	Hydroxylation	0.64	Medium	P197S