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. 2020 Mar 6;13:33. doi: 10.1186/s12920-020-0695-0

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© The Author(s). 2020

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Enhancer activation in metastatic cells. a Bar plots of the number of significantly decreased (down) and increased (up) H3K27ac peaks in the indicated comparison. b Number of significant gene expression changes associated with significant differential linked enhancer activation plotted as in A. c Genome track view of the promoter region of EMP2 and its promoter-enhancer linkages. d Genome track view of the promoter region of RIMS2 and its promoter-enhancer linkages. All significant peaks defined by p < 0.05, as determined by DESeq2 and BH correction. Genome track heights were scaled within each histone modification, ATAC signal, or RNA pile-up