Fig. 7.

Expression of TFs associated with remodeled chromatin regions correlates with site-specific metastatic relapse. a-d Examples of Kaplan-Meier curves of TF expression in lung metastasis-free (a), brain metastasis-free (b), or both lung and brain metastasis-free (c, d) survival. Human breast tumors from independent institutes were compiled and classified as “high” or “low” based on whether TF expression was above or below the median, respectively. Common up, associated with both lung and brain metastasis; Common down, negatively associated with both lung and brain metastasis. P values were calculated by log-rank test. n = 223