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. 2020 Mar 6;11:106. doi: 10.1186/s13287-020-01591-0

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© The Author(s) 2020

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Proteomic changes in response to ischemia and CAC treatment. a Functional classification of identified proteins based on Gene Ontology Database (via ProteomeDiscoverer). b Volcano plots obtained after label free quantification, comparing protein levels in SE and SC, on days 2 and 4. Cut-off limits: p value < 0.05 and ratios for upregulated (> 1.5) or downregulated (< 0.6) proteins. Color legends: upregulated () or downregulated () proteins, no significant changes (). c Principal component analysis (PCA) graph distributed groups (SE, SC, SH, and C) mainly between controls and ischemic mice, but also per time (controls, day 2 and day 4). d Venn’s diagram showing the overlapping of proteins differently expressed between SC and SH and also between SE/SC on both days analyzed. e Number of proteins upregulated (red) and downregulated (green) by ischemia (SC/SH) and in response to CAC treatment (SE/SC) per day. f Validation by WB of proteomic results. As an example, the results seen for ApoE are shown. Apo-E was upregulated in SC and SE mice compared to controls

Inline graphic — Proteomic changes in response to ischemia and CAC treatment. a Functional classification of identified proteins based on Gene Ontology Database (via ProteomeDiscoverer). b Volcano plots obtained after label free quantification, comparing protein levels in SE and SC, on days 2 and 4. Cut-off limits: p value < 0.05 and ratios for upregulated (> 1.5) or downregulated (< 0.6) proteins. Color legends: upregulated () or downregulated () proteins, no significant changes (). c Principal component analysis (PCA) graph distributed groups (SE, SC, SH, and C) mainly between controls and ischemic mice, but also per time (controls, day 2 and day 4). d Venn’s diagram showing the overlapping of proteins differently expressed between SC and SH and also between SE/SC on both days analyzed. e Number of proteins upregulated (red) and downregulated (green) by ischemia (SC/SH) and in response to CAC treatment (SE/SC) per day. f Validation by WB of proteomic results. As an example, the results seen for ApoE are shown. Apo-E was upregulated in SC and SE mice compared to controls