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. 2020 Mar 6;18:38. doi: 10.1186/s12964-020-0519-z

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© The Author(s). 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Both Wnt/β-catenin and RAS signaling pathways are activated in CRC harboring CSC properties. a, b GSEA of CRC patient tissues (GSE13294, N = 125; GSE14333, N = 246) of the (a) canonical Wnt and (b) RAS pathways in the stem-like subtype of CRC tumors (GSE13294, N = 20; GSE14333, N = 55) and other differentiated CRC tumors. c Immunoblot analyses of CRC cell lines comparing CSC-like (CSC) and non-CSC-like (non-CSC) populations of CRC cell lines using the indicated antibodies. CSC and non-CSC-like population of CRC cells were sorted by FACS using CD44, CD133, and CD166 antibodies