Fig. 5.

Evaluating the propensity for CATCH(+) and CATCH(−) to self-associate. (A and B) Schematics of possible peptide organization within the nanofiber; green dots represent ¹³C labeling. (C) Isotopic dilution PITHIRDS-CT measurements of coassembled CATCH(+/−) nanofibers where only one peptide is ¹³C-labeled at a time. The asterisks in the plot legend indicate which peptide was isotopically labeled with ¹³C at the central atom. The dashed green curves correspond to simulations that account for the probabilities of like-neighbors for the ¹³C-labeled peptide as indicated by black arrows along the right vertical axis. Details describing these simulations can be found in SI Appendix.