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. 2020 Feb 18;117(9):4642–4652. doi: 10.1073/pnas.1919563117

Fig. 1.

Fig. 1.

Effects of BPA/BPS on placental gene expression. (A) PCA plot using the top quartile of the most variable genes across the samples. The color in the plot represents the different treatments, and sex is represented by the shape (females are triangles, and males are dots; each symbol represents a single biological replicate for a given group). TissueEnrich analyses of differentially expressed (DE) genes in BPA/BPA vs. control placenta. (B) Tissue-specific gene enrichment analysis of genes down-regulated in BPA or BPS relative to controls shows enrichment for genes with placenta-specific expression. (C) Heatmap showing expression levels for placenta-specific genes that were down-regulated in BPA or BPS relative to controls across tissues assayed in the mouse ENCODE Project. Placenta-specific genes were determined by TissueEnrich. Calm4, Coch, and Sfrp4 are highly expressed in placenta and a small subset of other tissues (group enriched), whereas Gm9513 is only expressed in the placenta. FPKM, fragments per kilobase of transcript per million mapped reads.