Fig. 7.

Circos plot correlations for BPA/BPS-exposed vs. control placenta that includes DEGs, 5-HT IHC, dopamine IHC, neurotransmitter concentrations, histological proportions of the placenta, steroid hormones, and significant metabolite differences. Correlation value was set to 0.8. Red lines in the center indicate a positive correlation (A), whereas blue lines indicate a negative correlation (B). Lines on the outside of the circle indicate whether the value was greater in BPA/BPS (blue) or controls (orange). For this analysis to work, each category has to include more than one end point. Thus, number of GCs, labyrinth to GC ratio, and placenta testosterone concentrations were included even though they did not show treatment differences.