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. 2020 Feb 18;117(9):4802–4808. doi: 10.1073/pnas.1921446117

Fig. 4.

Fig. 4.

Volcano plots of up-regulated/down-regulated genes in oxt and oxtr1 mutants. Log2foldChange of gene transcription levels in female mutants (A) and in male mutants (B) compared with those in WT fish. (C) Magnified views of the graph outlined by the dotted line in A and B. Each dot represents one gene. Gray dots indicate genes whose transcription levels were not significantly changed in mutants compared with those in WT (FDR > 0.05). Coral and light blue dots represent significantly up-regulated/down-regulated genes in mutants, respectively. Dark blue and blue dots indicate genes up-regulated in female mutants and involved in the GABA system and sodium ion homeostasis, respectively. Green dots represent genes down-regulated in both sexes of mutants and involved in the complement activation system. Horizontal dotted line represents a padj of 0.05.