Fig. 4.

HGT origin of EVE. (A) Box-plot describing the length of all genes in Phycodnaviruses (Phy), in the earliest plant species known to contain a putative EVE homolog (K. nitens, Kn), and the length of EVE-like genes across plant species (EVE), showing that EVE structure in plants resemble other viral genes. (B) SigHunt analysis of the K. nitens genome identifies a highly significant genomic island associated with a HGT event, at the location of the putative EVE homolog. The 1-kb window containing EVE was scored based on the number of the 4-mer frequencies that deviate from the credibility interval of their local genomic density, using a DIAS. (C) Density of DIAS in the K. nitens genome shows that high scores, such as that observed in the location of the putative EVE homolog, are rare.