Table 2.
Comparison of the Characteristics Stratified by the Presence of PH
| COPD Patients Without PH | COPD Patients with PH | p-value | |
|---|---|---|---|
| N | 143 | 40 | |
| Pulmonary artery pressure, mmHga | 27.0 (23.0–30.0) | 38.8 (36.0–53.0) | <0.01 |
| Age, yearsa | 73.0 (67.0–79.0) | 75.5 (71.3–80.0) | 0.04 |
| Sex, female, n (%)c | 17 (11.9) | 6 (15.0) | 0.60 |
| Smoking index, pack-yearsa | 46.0 (35.2–70.1) | 51.0 (37.9–68.9) | 0.84 |
| Current smokers, n (%)c | 15 (10.7) | 2 (5.1) | 0.29 |
| Cancer, n (%)c | 24 (21.4) | 11 (30.6) | 0.26 |
| Coronary artery disease, n (%)c | 15 (13.4) | 2 (5.6) | 0.20 |
| LTOT, n (%)c | 9 (11.0) | 2 (7.4) | 0.59 |
| Prescription of diuretics, n (%)c | 0(0%) | 8(5.6%) | 0.04 |
| Prescription of vasodilators, n (%)c | 0(0%) | 1(0.7%) | 0.48 |
| SpO2, %a | 96.0 (95.0–97.0) | 96.0 (95.0–97.0) | 0.75 |
| BMI, kg/m2b | 22.8 ± 3.0 | 21.6 ± 3.0 | 0.02 |
| CRP, mg/dla | 0.06 (0.03–0.20) | 0.07 (0.03–0.30) | 0.28 |
| WBC,/µLa | 6000 (5100–7400) | 6000 (5025–8000) | 0.60 |
| BNP, pg/mLa | 24.2 (11.9–47.2) | 33.1 (18.5–92.8) | 0.01 |
| LVEF, %a | 76.0 (72.0–80.0) | 74.0 (71.0–81.8) | 0.60 |
| IVC, cma | 1.3 (1.1–1.5) | 1.3 (1.0–1.4) | 0.97 |
| LVEDD, cmb | 4.4 ± 0.5 | 4.4 ± 0.7 | 0.96 |
| LVESD, cma | 2.7 (2.4–3.0) | 2.7 (2.4–3.2) | 0.64 |
Notes: Data are presented as the mean ± SD, median (IQR), or number (%). Data were compared between two groups using aMann–Whitney U-test, bStudent’s t-test, and cχ2 test.
Abbreviations: PH, pulmonary arterial hypertension; COPD, chronic obstructive pulmonary disease; LTOT, long-term oxygen therapy; SpO2, oxygen saturation of peripheral artery; BMI, body mass index; CRP, C-reactive protein; WBC, white blood cell count; BNP, brain natriuretic peptide; LVEF, left ventricular ejection fraction; IVC, inferior vena cava; LVEDD, left ventricular end-diastolic diameter; LVESD, left ventricular end-systolic diameter; SD, standard deviation; IQR, interquartile range.