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. 2020 Mar 3;13:641–652. doi: 10.2147/DMSO.S237451

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© 2020 Zhang et al.

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Effect of curcumin on podocyte activity and apoptosis induced by high glucose. (A–C) Podocytes were cultured with normal glucose (5.5 mM), high glucose (30 mmol/l) and curcumin at different concentrations (20, 40, 80 μM) for 48 or 72 h. The relative cell viability was assessed with CCK-8 and expressed as percent podocyte survival relative to that of the normal cells. (D and E) AV-FITC/PI staining was performed to quantify the apoptosis rates via ﬂow cytometry. (F) Western blot assay showed that the expression of anti-apoptotic protein Bcl-2 and pro-apoptotic protein Bax and caspase-3 in podocytes. Data were shown as mean±SD. *p<0.05 VS Normal. ^#p<0.05 VS HG: high glucose. (HG+cucumin): high glucose+curcumin. **p<0.01.***p<0.001. ^##p<0.01. ^###p<0.001.