Table 1.

Intrinsic plasticity of mPFC neurons related to conditioned fear and cocaine seeking behavior.

Behavior	Intrinsic Plasticity of Pyramidal Neurons	Mechanisms	References
Fear Conditioning Delay Contextual Trace	Depressed firing IL neurons/ No effect on PL neurons Depressed firing IL neurons Depressed firing IL-to-NAc neurons No affect on firing IL-to-BLA, PL-to-BLA or PL-to-NAc neurons Depressed firing IL neurons Increased firing IL-to-BLA neurons Depressed firing PL-to-BLA neurons	Increased sAHP Decreased input resistance Undetermined Increased sAHP Decreased spike threshold Decreased input resistance	Santini et al., 2008 Koppensteiner et al., 2019 Bloodgood et al., 2018 Soler-Cedeno et al., 2016 Song et al., 2015
Fear Extinction Delay Spontaneous recovery of fear Trace	Increased firing IL neurons Increased firing IL neurons Increased firing IL-to-NAc neurons Increased firing IL-to-BLA neurons Increased firing of IL neurons 4 hrs after extinction Depressed firing IL neurons Depressed firing IL-to-BLA neurons Increased firing PL-to-BLA neurons	Decreased sAHP/ increased fAHP Undetermined Undetermined Increased fAHP Decreased fAHP Increased spike threshold Increased input resistance	Santini et al., 2008 Koppensteiner et al., 2019 Bloodgood et al., 2018 Cruz et al.,2014 Cruz et al.,2014 Song et al., 2015
Cocaine 1 or 5 days of i.p.cocaine injections 3 days withdrawal from cocaine i.p. injections (5 days) 3 days withdrawal from cocaine i.p. injections (5 days) 2 days after CPP (8 days) 16 days of extinction from self-admin.(10 days) 1 day after self-admin. (14 days) 2 months self-admin. 4 days of shock sessions	Depressed firing PL GABAergic fast-spiking interneurons Increased firing PL neurons Increased firing PL neurons Increased firing PL neurons Increased firing PL neurons/ Depressed firing IL neurons Increase firing PL neurons Depressed firing PL neurons	Decreased resting membrane potential and threshold Decreased K+ inward rectifiers (Kir) and voltage-gated K+ current Reduced voltage-gated K+ currents Increased L-type calcium channel conductance Decreased fAHP in PL/ fAHP was not affected in IL Reduced spike frequency adaptation, AHP, and Kv7 channels Decreased input resistance/ increased spike threshold	Slaker et al., 2015 Nasif et al., 2005b Dong et al., 2015 Otis et al.,2018 Sepulveda-Orengo et al., 2018 Parrilla-Carrero et al., 2018 Chen et al., 2013